Ceftriaxone sodium CAS 104376-79-6

Introduction：Basic information about Ceftriaxone sodium CAS 104376-79-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ceftriaxone sodium Basic information

• Product Name: Ceftriaxone sodium
• Synonyms: (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate;Ceftriaxone sodiuM sesquaterhydrate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-;Ceftriaxone SodiuM Trihydrate;Ceftriaxone disodium salt hemiheptahydrate, >=98%;sodium 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:;Ceftriaxone (sodium salt hydrate)
• CAS: 104376-79-6
• MF: C18H21N8NaO8S3
• MW: 596.58
• EINECS: 626-956-4
• Product Categories: VESPRIN;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;API;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;A - KAntibiotics;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;Chemical Structure Class;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity;Ceftriaxone;Heterocycles;Sulfur & Selenium Compounds
• Mol File: 104376-79-6.mol

Ceftriaxone sodium Chemical Properties

• Melting point: 236 °C
• alpha: D25 -165° (c = 1 in water) (calc for water-free substance)
• refractive index: -160 ° (C=1, H2O)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: H2O: soluble50mg/mL
• pka: ~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
• form: powder or crystals
• color: White to Off-White
• Water Solubility: Freely soluble in water
• Major Application: pharmaceutical (small molecule)
• InChIKey: FDRNWTJTHBSPMW-BBJOQENWSA-L
• SMILES: C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NC(=O)C(=O)NN1C)(=O)O.[NaH].O |&1:5,7,r|

Safety Information

• Hazard Codes: Xn
• Risk Statements: 36/37/38-42/43
• Safety Statements: 26-36-45-37-24-22
• WGK Germany: 1
• RTECS: XI0368800
• HS Code: 29349990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3
• Toxicity: LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)

Ceftriaxone sodium Usage And Synthesis

Description

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.

Chemical Properties

White Crystalline Solid

Uses

antipsychotic

Uses

An antibacterial, a third-generation cephalosporin.

Uses

A potentially useful antibacterial agent for proteomics research.

Definition

ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.

Brand name

Rocephin (Roche).

Biological Activity

β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

References

[1] H. NEU F KWUNGP N Meropol. Antibacterial Activity of Ceftriaxone (Ro 13-9904), a β-Lactamase-Stable Cephalosporin[J]. Antimicrobial Agents and Chemotherapy, 1981, 19 1: 940-940. DOI: 10.1128/aac.19.5.940-b
[2] SIZHUANG YAN  Dennis L S  Paul M Mendelman. The in vitro antibacterial activity of ceftriaxone against Streptococcus pyogenes is unrelated to penicillin-binding protein 4[J]. Fems Microbiology Letters, 1993, 110 3: Pages 313-317.