cis-4-Hydroxycyclohexanecarboxylic acid CAS 3685-22-1

Introduction：Basic information about cis-4-Hydroxycyclohexanecarboxylic acid CAS 3685-22-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

cis-4-Hydroxycyclohexanecarboxylic acid Basic information

• Product Name: cis-4-Hydroxycyclohexanecarboxylic acid
• Synonyms: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;(1s,4s)-4-hydroxycyclohexanecarboxylic acid;RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-Hydroxycyclohexanecarboxylic Acid;Cyclohexanecarboxylic acid, 4-hydroxy-, cis-;cis-4-Hydroxycyclohexane-1-carboxylic acid;cis-4-HydroxycyclohexanecarboxylicAcid>(1s,4s)-4-hydroxycyclohexane-1-carboxylic acid
• CAS: 3685-22-1
• MF: C7H12O3
• MW: 144.17
• Product Categories: 4-Substituted Cyclohexanecarboxylic Acids
• Mol File: 3685-22-1.mol

cis-4-Hydroxycyclohexanecarboxylic acid Chemical Properties

• Melting point: 150°C
• Boiling point: 115 °C(Press: 8 Torr)
• density: 1.246
• storage temp.: 2-8°C
• solubility: almost transparency in Methanol
• form: powder to crystal
• pka: pK1:4.836 (25°C)
• color: White to Almost white
• InChI: InChI=1S/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+
• InChIKey: HCFRWBBJISAZNK-OLQVQODUSA-N
• SMILES: [C@@H]1(C(O)=O)CC[C@H](O)CC1
• CAS DataBase Reference: 3685-22-1

Safety Information

• Hazard Codes: T
• Risk Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: WGK 3
• HazardClass: 6.1
• HS Code: 2918199890
• Storage Class: 11 - Combustible Solids

cis-4-Hydroxycyclohexanecarboxylic acid Usage And Synthesis

Chemical Properties

White to Almost white powder to crystal. Melting point:148.0 to 152.0 °C.

Uses

Cis-4-Hydroxycyclohexanecarboxylic acid is a metabolite of p-hydroxybenzoic acid. It is the major metabolite in the urine of rats treated with exogenous p-hydroxybenzoic acid. It has been found to have immunosuppressive activities in rat hepatocytes, as well as metabolic disorders that are related to hyperglycemia or diabetes mellitus.

Definition

ChEBI: 4-Hydroxycyclohexylcarboxylic acid is a hydroxy monocarboxylic acid.

Synthesis

cis-4-Hydroxycyclohexanecarboxylic acid can be synthesized through the following steps:
1. In an argon glove box, dissolve ligands L1-(S,R)-f-ambinol (7.5mg, 0.0105mmol) and [Ir(COD)Cl]2 (3.4mg, 0.005mmol) in 1 mL of iPrOH in a 2mL vial and stir at room temperature for 2 h.
2. Put 1 mmol of raw material 4-substituted cyclohexanone into a 4 mL hydrogenation flask.
3. Add 0.1 mL of the in-situ complexed catalyst solution and 1.6 mg of tBuOLi solid powder to the hydrogenation flask.
4. Add 1 mL of EtOH to dissolve the reactants in the hydrogenation flask.
5. Put the reaction flask into the hydrogenation kettle and replace the kettle body with hydrogen three times.
6. Fill the kettle with 5bar H2 and react at room temperature for 12h.
7. After the reaction is completed, carefully release the hydrogen and spin-dry the solvent under reduced pressure.
8. Purify the hydrogenated product cis-4-substituted cyclohexanol by silica gel column.
9. Obtain the final product cis-4-Hydroxycyclohexanecarboxylic acid.

References

[1] Patent: CN105061424, 2016, B. Location in patent: Paragraph 0029; 0031

cis-4-Hydroxycyclohexanecarboxylic acid Preparation Products And Raw materials

• Raw materials: Cyclohexanecarboxylic acid, 4-hydroxy-, Methyl ester, cis--->4-Oxocyclohexanecarboxylic acid