Climbazole CAS 38083-17-9

Introduction：Basic information about Climbazole CAS 38083-17-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Climbazole Basic information

• Product Name: Climbazole
• Synonyms: 1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone;BAY MEB-6401;Diadimefon;MEB-6401;Climbazole 0.1;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole;Crinipan AD
• CAS: 38083-17-9
• MF: C15H17ClN2O2
• MW: 292.76
• EINECS: 253-775-4
• Product Categories: Aromatics;Heterocycles;Alpha sort;C;Intermediates & Fine Chemicals;Pharmaceuticals;Pesticide;CAlphabetic;CI - CLPesticides;Conazoles;Fungicides;Pesticides&Metabolites;38083-17-9
• Mol File: 38083-17-9.mol

Climbazole Chemical Properties

• Melting point: 96-100°C
• Boiling point: 447.5±40.0 °C(Predicted)
• density: 1.17±0.1 g/cm3(Predicted)
• vapor pressure: 0.001Pa at 25℃
• refractive index: 1.54
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Insoluble in water
• pka: 5.66±0.22(Predicted)
• form: Solid
• color: White to Almost white
• Water Solubility: 58mg/L at 25℃
• BRN: 618020
• Major Application: agriculture environmental
• Cosmetics Ingredients Functions: ANTIMICROBIAL PRESERVATIVE ANTI-SEBORRHEIC
• InChI: 1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3
• InChIKey: OWEGWHBOCFMBLP-UHFFFAOYSA-N
• SMILES: CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2
• LogP: 3.83 at 25℃
• CAS DataBase Reference: 38083-17-9(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn,N
• Risk Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 3077
• WGK Germany: 3
• RTECS: EL7085000
• HS Code: 29332900
• Storage Class: 13 - Non Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1

Climbazole Usage And Synthesis

Risks to the environment

Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms.

Description

(±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff.

Chemical Properties

White Solid

Uses

Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix. s assay and did not induce micronuclei in human lymphocytes.

Definition

ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether.

Hazard

Moderately toxic by ingestion. Low toxicity by skin contact.

Flammability and Explosibility

Non flammable

Side effects

May cause localized irritation of the skin with symptoms including redness, rashes and itching.

References

[1] P. CAVANA . Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs[J]. Journal de mycologie medicale, 2015, 25 4: Pages 268-273. DOI: 10.1016/j.mycmed.2015.10.004
[2] MARIOS STYLIANOU. Antifungal application of nonantifungal drugs.[J]. Antimicrobial Agents and Chemotherapy, 2014, 58 2: 1055-1062. DOI: 10.1128/aac.01087-13
[3] SCHMIDT D A. In vitro Activity of Climbazole, Clotrimazole and Silver-sulphadiazine against Isolates of Malassezia pachydermatis[J]. Zoonoses and Public Health, 2010, 44 1-10: 193-197. DOI: 10.1111/j.1439-0450.1997.tb00964.x
[4] A SCHMIDT  B R H. In vitro susceptibility of Malassezia furfur against azole compounds.[J]. Mycoses, 1996, 39 7-8: 309-312. DOI: 10.1111/j.1439-0507.1996.tb00145.x
[5] KOBAYASHI Y, SUZUKI M, OHSHIRO N, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450.[J]. The Journal of toxicological sciences, 2001, 62 1: 0. DOI: 10.2131/jts.26.141

Climbazole Preparation Products And Raw materials

• Raw materials: Imidazole-->Pyrazole-->3-Thiophenezoic acid
• Preparation Products: Methidathion