Cloperastine hydrochloride CAS 14984-68-0

Introduction：Basic information about Cloperastine hydrochloride CAS 14984-68-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Cloperastine hydrochloride Basic information

• Product Name: Cloperastine hydrochloride
• Synonyms: 1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE;CHLOPERASTINE HYDROCHLORIDE
• CAS: 14984-68-0
• MF: C20H25Cl2NO
• MW: 366.32
• EINECS: 239-067-8
• Mol File: 14984-68-0.mol

Cloperastine hydrochloride Chemical Properties

• Melting point: 147.9°
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• Merck: 14,2395
• Major Application: forensics and toxicology pharmaceutical (small molecule) veterinary
• InChI: InChI=1S/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H
• InChIKey: UNPLRYRWJLTVAE-UHFFFAOYSA-N
• SMILES: C(OCCN1CCCCC1)(C1C=CC=CC=1)C1=CC=C(Cl)C=C1.Cl
• CAS DataBase Reference: 14984-68-0(CAS DataBase Reference)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: TM6491500
• HS Code: 2933.39.9200
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

Cloperastine hydrochloride Usage And Synthesis

Uses

Antitussive;'Histamine antagonist

Uses

Cloperastine Hydrochloride is an anti-tussive drug as an over-the-counter cold medicine.

Definition

ChEBI: Cloperastine hydrochloride is a diarylmethane.

in vivo

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic?action potential (MAP) duration without affecting PR interval or QRS width^[1].
?Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD₅₀ in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively^[2].