columbamine CAS 3621-36-1

Introduction：Basic information about columbamine CAS 3621-36-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

columbamine Basic information

• Product Name: columbamine
• Synonyms: Dehydroisocorypalmine;5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium;5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol;Columbamine (Columbamin;Columbamin;Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-;3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol;Inhibitor,Columbamine,inhibit
• CAS: 3621-36-1
• MF: [C20H20NO4]+.
• MW: 0
• Mol File: 3621-36-1.mol

columbamine Chemical Properties

• Melting point: 280-282℃ (methanol )
• storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
• solubility: DMSO: soluble
• form: Powder
• color: Light yellow to orange

columbamine Usage And Synthesis

Chemical Properties

Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.

Uses

Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.

Definition

ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.

Biological Activity

Columbamine is a quaternary isoquinoline alkaloid extracted from plants.

in vivo

Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model^[4].

• Animal Model: Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)^[4]
• Dosage: 5, 10, 20 mg/kg
• Administration: Administered to experimental mice for 23 days
• Result: Decreased the tumor volumes in a dose-dependent manner.

IC 50

CYP3A4: 30.6 μM (IC₅₀)