Introduction：Basic information about Cremophor EL CAS 61791-12-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Cremophor EL Basic information
| Product Name: | Cremophor EL |
| Synonyms: | polyoxyethylene castor oil;POLYOXYETHYLENE(10) CASTOR OIL;POLYETHYLENEGLYCOL CASTOR OIL;Castoroil,ethyleneglycolpolymer;Castoroil,ethyleneoxidereactionproduct;Castoroil,polyethoxylated;castoroilpolyoxyethyleneether;polyethoxylatedcastoroil |
| CAS: | 61791-12-6 |
| MF: | NULL |
| MW: | 0 |
| EINECS: | 500-151-7 |
| Product Categories: | Detergents;Detergents A to ZDetergents;Non-Ionic |
| Mol File: | Mol File |
|
Cremophor EL Chemical Properties
| Boiling point | 232.6℃[at 101 325 Pa] |
| density | 1.05 g/mL at 20 °C |
| vapor pressure | 0Pa at 25℃ |
| Fp | 257℃ |
| storage temp. | REFRIGERATOR (+4C) |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 0[at 20 ℃] |
| form | Viscous Liquid |
| color | Clear yellow |
| Odor | at 100.00?%. bland |
| PH | 5.0-7.0 (1g/10 mL in H2O) |
| Water Solubility | 24.11mg/L at 25℃ |
| Stability: | Stable. Incompatible with storng oxidizing agents. |
| Cosmetics Ingredients Functions | SKIN CONDITIONING - EMOLLIENT
SURFACTANT - CLEANSING
SURFACTANT - EMULSIFYING |
| Cosmetic Ingredient Review (CIR) | Cremophor EL (61791-12-6) |
| InChI | 1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8) |
| InChIKey | JMNCUXPHXKHBPY-UHFFFAOYSA-N |
| SMILES | ClCC(OC(=O)N)CCl |
| LogP | 4.297 at 25℃ |
| CAS DataBase Reference | 61791-12-6 |
| EPA Substance Registry System | Ethoxylated castor oil (61791-12-6) |
Safety Information
| WGK Germany | 1 |
| RTECS | GO5661000 |
| TSCA | TSCA listed |
| HS Code | 15153090 |
| Storage Class | 11 - Combustible Solids |
Cremophor EL Usage And Synthesis
| Chemical Properties | light yellow liquid |
| Uses | Polyoxyl 35 Castor Oil is a triglyceride fatty acid which has the potential to repel insects and promote plant growth. |
| Uses | Kolliphor? EL has been used as a detergent to improve the solubility of dye and to increase the transmembrane permeation. It has been used as a vehicle for drug/stimulant delivery in cells. |
| General Description | Kolliphor? EL is a nonionic solubilizer and emulsifier made by reacting castor oil with ethylene oxide. It is a pale yellow oily liquid that is clear at temperatures above 26°C. It has a faint but characteristic odour. |
| Flammability and Explosibility | Not classified |
| Biochem/physiol Actions | Kolliphor? EL is used in lipid-based formulations for drugs and solubilization of cosmetics. Kolliphor EL is suitable for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds. Due to its emulsification functionality, it finds application in biological membrane- based drug transport studies. |
| Toxics Screening Level | An initial threshold screening level (ITSL) of 0.1 μg/m3 annual average. |
Cremophor EL Preparation Products And Raw materials
| Raw materials | Hydrogen peroxide-->Castor oil-->castor oil polyoxyethylene (90) ether |
| Preparation Products | pesticide emulsifier 0203B-->pesticide emulsifier 0206-->Pesticide emulsifier 0207-->Pesticide emulsifier S-118-->pesticide emulsifier 0208-->pesticide emulsifier 0206B-->pesticide emulsifier 0205 |
