Dantrolene sodium salt CAS 14663-23-1

Introduction：Basic information about Dantrolene sodium salt CAS 14663-23-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Dantrolene sodium salt Basic information

• Product Name: Dantrolene sodium salt
• Synonyms: Dantrolene Sodium Salt 1-[[5-(p-Nitrophenyl)furfurylidene]amino]-hydantoin sodium salt anhydrous;DantroloneSodium;SODIUM DANTROLENE;1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]-2,4-IMIDAZOLINEDIONE SODIUM SALT;1-[[[5-(4-NITROPHENYL)-2-FURANYL]-METHYLENE]IMINO]2,4-IMIDAZOLIDINEDIONE SODIUM SALT;1-[(5-[P-NITROPHENYL]FURFURYLIDENE)-AMINO]HYDANTOIN SODIUM SALT;DANTRIUM
• CAS: 14663-23-1
• MF: C14H11N4NaO5
• MW: 338.25
• EINECS: 238-706-8
• Product Categories: pharmacetical;API's;InsP3/Ryanodine receptor;Cardiovascular APIs
• Mol File: 14663-23-1.mol

Dantrolene sodium salt Chemical Properties

• storage temp.: Store at RT
• solubility: Soluble in DMSO (up to 3 mg/ml)
• form: Orange solid
• color: Orange
• Merck: 14,2816
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF/ethanol may be stored at -20°C for up to 1 month.
• InChI: InChI=1S/C14H10N4O5.Na.H/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;;/h1-7H,8H2,(H,16,19,20);;/b15-7+;;
• InChIKey: KSRLIXGNPXAZHD-HAZZGOGXSA-M
• SMILES: C(/C1=CC=C(C2C=CC(N(=O)=O)=CC=2)O1)=N\N1C(NC(=O)C1)=O.[NaH]
• CAS DataBase Reference: 14663-23-1(CAS DataBase Reference)

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: 2
• RTECS: MU3875000
• HS Code: 2942.00.3500
• Storage Class: 11 - Combustible Solids

Dantrolene sodium salt Usage And Synthesis

Description

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC₅₀ = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with K_d values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC₅₀ values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC₅₀ = 3 μg/ml) and MHS pigs (ED₅₀ = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.

Chemical Properties

mp 279-280C 3415821

Uses

Skeletal muscle relaxant;Blocker of Ca2+ release

Uses

Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

Definition

ChEBI: The anhydrous sodium salt of dantrolene.

Brand name

Dantrium (Procter & Gamble).

Biological Activity

Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.

storage

Store at RT

References

[1] Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity
[2] A FRANDSEN  A S. Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionate and kainate in cultured cerebral cortical neurons.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89 7: 2590-2594. DOI:10.1073/pnas.89.7.2590
[3] SUSANNE MUEHLSCHLEGEL J R S. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit.[J]. Neurocritical Care, 2009, 10 1: 103-115. DOI:10.1007/s12028-008-9133-4
[4] SIMIN LU. A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014: E5292-301. DOI:10.1073/pnas.1421055111