Introduction：Basic information about defibrotide CAS 83712-60-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
defibrotide Basic information
| Product Name: | defibrotide |
| Synonyms: | defibrotide;Dasovas;Defibrinotide;Fraction p;Noravid;Prociclide;defibrotide USP/EP/BP;Defibrotide Impurity 2 |
| CAS: | 83712-60-1 |
| MF: | |
| MW: | 0 |
| EINECS: | 202-303-5 |
| Product Categories: | |
| Mol File: | Mol File |
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defibrotide Chemical Properties
| form | Liquid |
| color | Colorless to light yellow |
Safety Information
| Toxicity | LD50 intraperitoneal in dog: > 600mg/kg |
defibrotide Usage And Synthesis
| Description | Defibrotide is an antithrornbotic, partially-depolymerized polydeoxyribonucleotideobtained from bovine lungs. It is reported to be useful in the treatment ofmyocardial and severe lower limb ischemia, renal failure due to thromboticmicroangiopathy, and thrombophlebitis, and in the prophylaxis of deep vein thrombosis, possibly via PCI2 stimulation. |
| Originator | Crinos (Italy) |
| Uses | Defibrotide sodium is a complex mixture of single stranded polydeoxyribonucleotides. Defibrotide sodium has liver protection, anti-inflammatory, antithrombotic, profibrinolytic, and anti-ischemic properties. Defibrotide sodium can be used for sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) research[1]. |
| Brand name | NORAVID; PROCICLIDE |
| in vivo | Intracarotid (i.c.) administration of Defibrotide sodium (64 mg/kg bolus plus 64 mg/kg/h for 1 h) prior to i.c. thrombin (100 μg/kg) significantly reduces the ability of thrombin to induce cranial thromboembolism in rabbits[2].
Intravenous (i.v.) administration of thrombin (20 μg/kg) in rabbits induces a reversible accumulation of radiolabelled platelets into the thoracic circulation which is significantly reduced by i.v. administration of defibrotide (64 mg/kg bolus plus 64 mg/kg/h for 1 h) prior to i.v. thrombin[2].
Intravenous injection of human thrombin (1250 μg/kg) to mice induces death within the majority of animals which is significantly reduced by pretreatment with defibrotide (150-175 mg/kg, i.v.)[2].
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| References | [1] May T Aziz, et al. Defibrotide: An Oligonucleotide for Sinusoidal Obstruction Syndrome. Ann Pharmacother. 2018 Feb;52(2):166-174. DOI:10.1177/1060028017732586
[2] W Paul, et al. The effect of defibrotide on thromboembolism in the pulmonary vasculature of mice and rabbits and in the cerebral vasculature of rabbits. Br J Pharmacol. 1993 Dec;110(4):1565-71. DOI:10.1111/j.1476-5381.1993.tb14002.x |
defibrotide Preparation Products And Raw materials
