Desflurane CAS 57041-67-5
Introduction：Basic information about Desflurane CAS 57041-67-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Desflurane Basic information
| Product Name: | Desflurane |
| Synonyms: | DIFLUOROMETHYL 1,2,2,2-TETRAFLUOROETHYL ETHER;DESFLURANE;1,2,2,2-TETRAFLUOROETHYL DIFLUOROMETHYL ETHER;(2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane;Difluoromethyl 1,2,2,2-tetrafluoroethyl ether 99%;Difluoromethyl1,2,2,2-tetrafluoroethylether99%;i653;Suprane |
| CAS: | 57041-67-5 |
| MF: | C3H2F6O |
| MW: | 168.04 |
| EINECS: | |
| Product Categories: | refrigerants |
| Mol File: | 57041-67-5.mol |
Desflurane Chemical Properties
| Boiling point | 23-24°C |
| density | 1,47 g/cm3 |
| refractive index | 1.3577 (estimate) |
| solubility | Practically insoluble in water, miscible with anhydrous ethanol. |
| form | liquid |
| color | Clear |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H |
| InChIKey | DPYMFVXJLLWWEU-UHFFFAOYSA-N |
| SMILES | FC(F)(F)C(F)OC(F)F |
| CAS DataBase Reference | 57041-67-5(CAS DataBase Reference) |
| EPA Substance Registry System | Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-, (+-)- (57041-67-5) |
Safety Information
| Hazard Codes | Xi |
| Safety Statements | 23 |
| WGK Germany | WGK 3 |
| Hazard Note | Irritant |
| HazardClass | GAS |
| HS Code | 2909191800 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 Repr. 2 STOT SE 3 |
| Hazardous Substances Data | 57041-67-5(Hazardous Substances Data) |
| Description | Desflurane is a new inhalation anesthetic introduced for induction and maintenance ofgeneral anesthesia in adults. Due to reports of respiratory irritation, desflurane may beused only for maintenance in children. Although almost structurally identical toisoflurane, a halogen replacement gives desflurane an improved pharmacokineticprofile. It is less soluble in blood and tissue and produces a fast onset of action and amore rapid recovery from anesthesia. |
| Chemical Properties | Desflurane is a clear, colourless, mobile, heavy liquid. It is similar to isoflurane (CHF2-O-CHCl-CF3) in that both are halogenated compounds of methyl ethane, except that chlorine is replaced with fluorine in the α-ethyl portion. The halogenation of fluorine reduces the solubility of blood and tissues and alters the boiling point, vapor pressure and stability of desflurane, enhancing its molecular stability as well as its resistance to biodegradation and alkaline degradation. |
| Originator | Anaquest (BOC Healthcare) (U.S.A.) |
| History | Desflurane was first synthesized by Russel et al U.S. at the 29. of July 1975. The synthesis was started by using floural methyl hemiacetal (CF3CH(OH)OCH3) and converting it to 1,2,2,2- tetraflouroethyl methyl ether (CF3CHFOCH3). Next step was chlorinating two hydrogen atoms of the methyl-group to CF3CHFOCHCl2. This next to last molecule was charged with HF in the presence of antimony pentachloride (SBCL5) to Desflurane. But this way of synthesizing Desfluran was not usable for industrial synthesis, because of the less yield of Desflurane and the expensive educts. |
| Uses | Anesthetic. |
| Preparation | Isoflurane and bromine trifluoride were reacted overnight at room temperature to synthesize desflurane in 62% yield. |
| Definition | ChEBI: Desflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane. |
| Brand name | Suprane (BaxterHealthcare). |
| Biological Functions | Desflurane (Suprane) shares most of the pharmacologicalproperties of isoflurane. Desflurane has low tissueand blood solubility compared with other halogenatedhydrocarbons, and its anesthetic partial pressure is thusestablished more rapidly. Recovery is similarly promptwhen the patient is switched to room air or oxygen.Desflurane’s popularity for outpatient procedures stemsfrom its rapid onset and prompt elimination from thebody by exhalation. A disadvantage is that desflurane irritatesthe respiratory tract; thus, it is not preferred forinduction of anesthesia using an inhalational technique.However, desflurane may be used to maintain anesthesiaafter induction with an alternative IV or inhalationalagent, preserving the advantage of rapid recovery. Desflurane, like other halogenated hydrocarbonanesthetics, causes a decrease in blood pressure.The reducedpressure occurs primarily as a consequence ofdecreased vascular resistance, and since cardiac outputis well maintained, tissue perfusion is preserved. Desflurane stimulates the sympathetic nervous systemand causes abrupt transient tachycardia during inductionor as the concentration of the agent is raised tomeet the patient’s changing needs. Desflurane causes an increase in the rate of ventilation,a decrease in tidal volume, and a decrease inminute volume as inspired concentrations only slightlyexceed 1 MAC. Thus should anesthesiologists requiredesflurane to be administered near or above MAC levels,patients are likely to have marked reductions inPCO2. |
| General Description | Desflurane is a nonflammable, colorless, very volatile liquidpackaged in amber-colored vials. The boiling point is22.8°C, and it requires a vaporizer specifically designed fordesflurane. The manufacturer states that the vials can bestored at room temperature. Desflurane has a blood:gas partitioncoefficient of 0.42, an MAC of 7.3% and an oil:gaspartition coefficient of 18.7. The low blood:gas partition coefficientleads to fast induction times and short recoverytimes. Desflurane is not recommended for induction anesthesiain children because of the high incidence of laryngospasms(50%), coughing (72%), breath holding (68%),and increase in secretions (21%). Desflurane can producea dose-dependent decrease in blood pressure and concentrationsexceeding 1 MAC may cause transient increases inheart rate. Desflurane can react with desiccated carbon dioxideabsorbents to produce carbon monoxide that may resultin elevated levels of carboxyhemoglobin.24. |
| Metabolism | Desflurane is not metabolized to any great extent and, therefore, has not been associated with hepatotoxicity or nephrotoxicity. Metabolites, mostly trifluoroacetate, account for less than 0.02% of the administered dose. Whereas desflurane can react with soda lime or Baralyme to form carbon monoxide, no reports of adverse outcomes in patients have appeared. |
Desflurane Preparation Products And Raw materials
| Raw materials | Isoflurane-->Desflurane-->Ethane, 2-(dichloromethoxy)-1,1,1,2-tetrafluoro--->BROMINE TRIFLUORIDE |
| Preparation Products | Ethane, pentafluoro(trifluoromethoxy)--->2-Chloro-1,1,1,2-tetrafluoroethane |
