Dexketoprofen trometamol CAS 156604-79-4

Introduction：Basic information about Dexketoprofen trometamol CAS 156604-79-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Dexketoprofen trometamol Basic information

• Product Name: Dexketoprofen trometamol
• Synonyms: 2-AMino-2-(hydroxyMethyl)propane-1,3-diol (S)-2-(3-benzoylphenyl)propanoate;D-ketoprofen troMethaMine;(S)-Ketoprofen Tromethamine Salt (Dexketoprofen Trometamol);(S)-(+)-Form tromethamine salt;Dexketoprofen Trometamol Tablets;Dexketoprofen Trometamol（Ketorolac,KETOROL,Ketanov, TORADOL, Toratex, Tromethamine）;2-amino-2-(hydroxymethyl)propane-1,3-diol,2-(3-benzoylphenyl)propanoic acid;(s)-ketoprofen trometamol
• CAS: 156604-79-4
• MF: C20H25NO6
• MW: 375.42
• EINECS: 605-065-4
• Product Categories: API;Other APIs;156604-79-4
• Mol File: 156604-79-4.mol

Dexketoprofen trometamol Chemical Properties

• Melting point: 104.8-105.1°
• alpha: D20 -5.2° (c = 1.47 in methanol)
• storage temp.: 2-8°C
• solubility: DMSO, Ethanol (Slightly), Methanol (Sparingly)
• form: Solid
• color: White to Off-White
• Major Application: pharmaceutical small molecule
• InChI: InChI=1/C16H14O3.C4H11NO3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12;5-4(1-6,2-7)3-8/h2-11H,1H3,(H,18,19);6-8H,1-3,5H2/t11-;/s3
• InChIKey: QUZMDHVOUNDEKW-XAAIUDFWNA-N
• SMILES: C(N)(CO)(CO)CO.C(C1C=CC=CC=1)(C1C=CC=C([C@H](C)C(=O)O)C=1)=O |&1:20,r|

Safety Information

• WGK Germany: WGK 3
• HS Code: 2922199695
• Storage Class: 11 - Combustible Solids

Dexketoprofen trometamol Usage And Synthesis

Uses

Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.

Uses

Mild to moderate pain Musculo-skeltal pain Dysmenorrhea Dental pain

Synthesis

In dextroketoprofen were added anhydrous ethanol, ethyl acetate and aminobutanetriol, the weight ratio of dextroketoprofen: anhydrous ethanol: ethyl acetate: aminobutanetriol = 1: 2: 7: 0.48, stirring, reflux for 30 minutes, filtered to the crystallization tank while still hot, condensate to 28 ~ 32 ??, open ice brine down to 10 ?? below the static 3 hours, centrifugation, the cake was washed 2 times with 1 wt. anhydrous ethanol and 7 wt. ethyl acetate mixed solution, centrifugation, filtrate distillation recovery, the cake was dried at 50 ?? for 10 hours, crushed, that is, the dextroketoprofen. The filter cake is washed with 1 wt. of anhydrous ethanol and 7 wt. of ethyl acetate mixed solution for 2 times, centrifugation, filtrate distillation and recovery, the filter cake is dried at 50 ?? for 10 hours, crushed, that is, the finished product of dextroketoprofen aminobutanetriol.