Introduction：Basic information about D-Glucurone CAS 32449-92-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
D-Glucurone Basic information
| Product Name: | D-Glucurone |
| Synonyms: | D-Glucurono-6,3-lactoneD-Glucuronic Acid LactoneD(+)-Glucurono-3,6-lactoneD-(+)-Glucuronic acid γ-lactone Glucuronolactone;D-(+)-Glucuronolactone for synthesis;b-d-anhydroglucuronate;d-glucurono-gamma-lactone;D-Glucuronic acid, g-lactone;D-Glucorono-6,3-lactone;Glucorolactone;D(+)-Glucurono-3,6-lactoneSynonyM: D-Glucurone |
| CAS: | 32449-92-6 |
| MF: | C6H8O6 |
| MW: | 176.12 |
| EINECS: | 251-053-3 |
| Product Categories: | Biochemistry;Glucose;Sugar Acids;Sugars;Dextrins、Sugar & Carbohydrates;Miscellaneous Natural Products;Carbohydrates & Derivatives;carbohydrate;bulk drug material， food addictive;Halogenated Heterocycles;API;32449-92-6 |
| Mol File: | 32449-92-6.mol |
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D-Glucurone Chemical Properties
| Melting point | 172-175 °C (lit.) |
| alpha | 19 º (c=10, H2O) |
| Boiling point | 227.71°C (rough estimate) |
| density | 1,76 g/cm3 |
| refractive index | 18.5 ° (C=5, H2O) |
| storage temp. | Store below +30°C. |
| solubility | water: soluble25mg/mL, clear, colorless |
| pka | 11.96±0.60(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White |
| Odor | at 100.00 %. very mild mentholic |
| Odor Type | mentholic |
| Optical Rotation | [α]24/D +18.8°, c = 8 in H2O |
| Water Solubility | SOLUBLE |
| Merck | 14,4467 |
| BRN | 83595 |
| Major Application | clinical testing |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| InChI | 1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1 |
| InChIKey | OGLCQHRZUSEXNB-IEPORWDDSA-N |
| SMILES | O=C([C@@H]([C@@H](O1)[C@H](O)[C@H](O)C1=O)O)[H] |
| LogP | -3.457 (est) |
| CAS DataBase Reference | 32449-92-6(CAS DataBase Reference) |
| EPA Substance Registry System | D-Glucuronolactone (32449-92-6) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS | LZ8930000 |
| TSCA | TSCA listed |
| HS Code | 29322980 |
| Storage Class | 11 - Combustible Solids |
D-Glucurone Usage And Synthesis
| Chemical Properties | white crystals or crystalline powder |
| Uses | D-Glucurone is a glucuronic acid derivative. It is used for treating canine hepatitis. |
| Uses | D-Glucurono-6,3-lactone is a glucuronic acid derivative studied for its effectiveness against canine hepatitis. It is utilized in the studies such as starting regent in the synthesis of 2,3,4,-tris(tert.-butyldimethysilyl) glucuronic acid trichloroethylester, required for the preparation of 1-O-acyl glucuronide of the anti-inflammatory drug ML-3000, synthesis of optically active glucopyranoses, synthesis of long-chain alkyl glucofuranosides. |
| Definition | The γ-lactone of glucuronic acid. Found in plant gums and animal connective tissues. |
| General Description | D-(+)-Glucuronic acid γ-lactone (Glucourono-γ-lactone, Glucurone or Glycurone) is a carbohydrate derivative. It converted into L-ascorbic acid in animals and human body. Its molecule contains two five-membered rings. Its crystal structure has been studied. |
| Purification Methods | Dissolve the lactone or mixture of lactone and acid in H2O and concentrate on a steam bath until crystallisation begins. Cool rapidly to room temperature wih stirring. After 2hours the product is filtered off, washed with cold EtOH and dried to m 174-175o and [] D +19.8o (c 5.2, H2O). The amount of free acid can be obtained by titration of an ice-cold aqueous solution with standard alkali. It can be recrystallised from EtOH, EtOH/H2O or MeOH, and the highest recorded m is 180o. [Stacey J Chem Soc 1529 1939, Mehltretter et al. J Am Chem Soc 73 2424 1951, Beilstein 18 III/IV 3055, 18/5 V 33.] |
D-Glucurone Preparation Products And Raw materials
| Raw materials | DOWEX MAC-3 ION EXCHANGE RESIN-->D-Glucuronic acid |
