Dibenzyl phosphate CAS 1623-08-1

Introduction：Basic information about Dibenzyl phosphate CAS 1623-08-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Dibenzyl phosphate Basic information

• Product Name: Dibenzyl phosphate
• Synonyms: DIBENZYL PHOSPHATE;DIBENZYL PHOSPHATE FREE ACID*CRYSTALLINE;PHOSPHORIC ACID DIBENZYL ESTER;dibenzyl hydrogen phosphate;DIBENZYLOXYPHOSPHOCREATININE;Dibenzyl phosphate impurity;Fosaprepitant Impurity N;Creatine Phosphate Disodium Impurity
• CAS: 1623-08-1
• MF: C14H15O4P
• MW: 278.24
• EINECS: 216-602-3
• Product Categories: Organic Building Blocks;Organic Phosphates/Phosphites;Fluorobenzene;Heterocyclic Compounds;Benzenes;Phosphorus Compounds
• Mol File: 1623-08-1.mol

Dibenzyl phosphate Chemical Properties

• Melting point: 78-80 °C (lit.)
• Boiling point: 427.6±48.0 °C(Predicted)
• density: 1.280±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly)
• form: Powder
• pka: 1.53±0.50(Predicted)
• color: White to slightly yellow
• BRN: 2055755
• Stability: Moisture Sensitive
• InChI: InChI=1S/C14H15O4P/c15-19(16,17-11-13-7-3-1-4-8-13)18-12-14-9-5-2-6-10-14/h1-10H,11-12H2,(H,15,16)
• InChIKey: HDFFVHSMHLDSLO-UHFFFAOYSA-N
• SMILES: P(O)(OCC1=CC=CC=C1)(OCC1=CC=CC=C1)=O
• CAS DataBase Reference: 1623-08-1(CAS DataBase Reference)

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: 3
• HS Code: 29199000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Eye Dam. 1

Dibenzyl phosphate Usage And Synthesis

Chemical Properties

white to slightly yellow powder

Uses

Eye irritant.

Uses

Dibenzyl phosphate (DBzP) can be used:

• To promote the monoselective ortho-C-H alkylation of N-quinolyl benzamides with primary and secondary alkyl iodides.
• For the ring-opening reaction of epoxide such as benzylglycidol to synthesize dihydroxyacetone phosphate (DHAP).
• As a reactant for the synthesis of stereospecific 1,2-trans glycosyl phosphates.

Definition

ChEBI: Dibenzyl phosphate is a dialkyl phosphate.

Synthesis

(1) benzyl alcohol, phosphorus trichloride, triethylamine in toluene reacted to form dibenzyl phosphite (purity 69%);

(2) dibenzyl phosphite, aqueous sodium hydroxide in carbon tetrachloride reacted to form dibenzyl phosphate sodium salt tetrahydrate (purity 95%), the two-step yield was 46.8%;

(3) dibenzyl phosphate sodium salt tetrahydrate reacted with hydrochloric acid to form dibenzyl phosphate (purity 97%), yield 85.6%;

(4) refined by ethyl acetate/petroleum ether = 1:3 (purity 99.5%), yield 88.1%

Dibenzyl phosphate Preparation Products And Raw materials

• Preparation Products: Tetrabenzyl pyrophosphate