Introduction：Basic information about Dibucaine hydrochloride CAS 61-12-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dibucaine hydrochloride Basic information
| Product Name: | Dibucaine hydrochloride |
| Synonyms: | 2-butoxy-n-(2-(diethylamino)ethyl)-4-quinolinecarboxamidmonohydrochlorid;Dibucaine (Cinchocaine) HCl;2-butoxy-n-(2-(diethylamino)ethyl)-cinchoninamidmonohydrochloride;2-butoxy-n-(2-diethylaminoethyl)cinchoninicacidamidehydrochloride;2-n-butoxy-n-(2-diethylaminoethyl)cinchoninamidehydrochloride;4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-,monohydrochloride;benzolin(localanesthetic);butoxycinchoninicaciddiethylethylenediamidehydrochloride |
| CAS: | 61-12-1 |
| MF: | C20H30ClN3O2 |
| MW: | 379.92 |
| EINECS: | 200-498-1 |
| Product Categories: | API;NUPERCAINAL;Other APIs;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol File: | 61-12-1.mol |
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Dibucaine hydrochloride Chemical Properties
| Melting point | 99-101 °C(lit.) |
| density | 1.1338 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Hygroscopic crystals |
| PH | pH(20g/l,25℃) : 5.0～6.0 |
| Water Solubility | Freely soluble in water, alcohol, acetone, or chloroform |
| Merck | 13,3057 |
| Stability: | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| Major Application | forensics and toxicology
pharmaceutical (small molecule) |
| InChI | InChI=1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H |
| InChIKey | IVHBBMHQKZBJEU-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC1=NC(OCCCC)=CC=2C(=O)NCCN(CC)CC.Cl |
| CAS DataBase Reference | 61-12-1(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| RTECS | GD3325000 |
| HS Code | 2933492250 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | eye-rbt 2% SEV ARZNAD 8,181,58 |
Dibucaine hydrochloride Usage And Synthesis
| Chemical Properties | white powder |
| Uses | Anesthetic (local). |
| Uses | Cinchocaine is used as an anaesthetic agent for spinal anaesthesia; a component in rectal medications used in inflammation of theanus and for the symptomatic treatment of hemorrhoids and fissures in the anus; local anesthetic agent. |
| Uses | Dibucaine HCl is an amide-like quinoline derivative and is one of the most potentand longest acting of the commonly used local anesthetics. |
| Definition | ChEBI: The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions. |
| Brand name | Nupercaine (Novartis). |
| Biological Activity | Potent, long-acting local anesthetic |
| Contact allergens | Dibucaine hydrochloride is an amide group local anestheticthat can induce allergic contact dermatitis. |
| Safety Profile | Poison by ingestion,subcutaneous, intravenous, intraspinal, parenteral, andintraperitoneal routes. Mutation data reported. A severeeye irritant. A local anesthetic. When heated todecomposition it emits very toxic fumes of HCl and NOx |
Dibucaine hydrochloride Preparation Products And Raw materials
| Raw materials | Dibutyl ether-->3-METHOXYPROPIONIC ACID-->2-Quinolinol-->Cinchocaine |
