Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate CAS 1149-23-1
Introduction：Basic information about Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate CAS 1149-23-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Basic information
| Product Name: | Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate |
| Synonyms: | DILUDINE;DIETHYL 2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE;DIETHYL 2,6-DIMETHYL-1,4-DIHYDROPYRIDINEDICARBOXYLATE;DIETHYL 1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE;AURORA 4780;3,5-DICARBETHOXY-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE;3,5-BIS(CARBOETHOXY)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE;2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID DIETHYL ESTER |
| CAS: | 1149-23-1 |
| MF: | C13H19NO4 |
| MW: | 253.29 |
| EINECS: | 214-561-6 |
| Product Categories: | Pyridines, Pyrimidines, Purines and Pteredines;C9 to C46;Heterocyclic Building Blocks;Pyridines;Pharmaceutical Intermediates;C9 to C46;Heterocyclic Building Blocks;fine chemicals, specialty chemicals, intermediates, electronic chemical, organic synthesis, pharmaceutical intermediates;Heterocycle-Pyridine series;Building Blocks;C13 to C15;Chemical Synthesis;1149-23-1 |
| Mol File: | 1149-23-1.mol |
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Chemical Properties
| Melting point | 178-183 °C(lit.) |
| Boiling point | 351.8±42.0 °C(Predicted) |
| density | 1.104±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in organic solvents. |
| pka | 3.50±0.70(Predicted) |
| form | Solid |
| color | Yellow |
| λmax | 374nm(EtOH)(lit.) |
| InChI | InChI=1S/C13H19NO4/c1-5-17-12(15)10-7-11(13(16)18-6-2)9(4)14-8(10)3/h14H,5-7H2,1-4H3 |
| InChIKey | LJXTYJXBORAIHX-UHFFFAOYSA-N |
| SMILES | C1(C)NC(C)=C(C(OCC)=O)CC=1C(OCC)=O |
| CAS DataBase Reference | 1149-23-1(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 2 |
| RTECS | US7970100 |
| HS Code | 29333990 |
| Toxicity | LD50 oral in dog: > 12gm/kg |
| Chemical Properties | Light green solid |
| Uses | Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is a hydrogen source in conjugate reduction and organocatalytic reductive amination. It is used as a hydrogen source in organocatalytic reductive amination and conjugate reduction. |
| Uses | 3,5-Dicarboethoxy-2,6-dimethyl-1,4-dihydropyridine is a dihydropyridine derivative that have been tested for antimicrobial activities. |
| Application | Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (DTP) was used to study the mechanism of electrochemical oxidation of DTP in ethanol/water solutions on a glassy carbon electrode. |
| Hazard | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Toxicology | ratLD50intraperitoneal>16 gm/kg mouseLD50oral>32 gm/kg mouseLD50intraperitoneal>30 gm/kg dogLD50oral>12 gm/kg |
| Synthesis | Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate is prepared by the reaction of formaldehyd and ethyl acetoacetate in the presence of an inert gas. |
| Synthesis | Hantzsch Dihydropyridine (Pyridine) Synthesis reaction allows the preparation of dihydropyridine derivatives by condensation of an aldehyde with two equivalents of a β-ketoester in the presence of ammonia. Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate can be produced by using this method. |
| Purification Methods | recrystallization from EtOH or flash chromatography with petroleum/ethyl acetate (7:3) |
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Preparation Products And Raw materials
| Raw materials | Ethanol-->Hexamethylenetetramine |
| Preparation Products | Glutaraldehyde-->Imazosulfuron-->Nilvadipine-->Nicardipine-->Benidipine-->pyridine-2,3,5,6-tetracarboxylic acid |
