Introduction：Basic information about Diethyl phosphite CAS 762-04-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Diethyl phosphite Basic information
| Product Name: | Diethyl phosphite |
| Synonyms: | diethylacidphosphite;diethylfosfit;Ethyl phosphonate ((EtO)2HPO);Diethyl phosphite,98%;Phosphorous acid diethyl;Phosphorous acid hydrogen diethyl;Phosphonic acid diethyl;Phosphonic Acid Diethyl EsterDiethyl PhosphonatePhosphorous Acid Diethyl Ester |
| CAS: | 762-04-9 |
| MF: | C4H11O3P |
| MW: | 138.1 |
| EINECS: | 212-091-6 |
| Product Categories: | Organic Building Blocks;Organic Phosphates/Phosphites;Catalysis and Inorganic Chemistry;Phosphorus Compounds;Phosphorus Precursors;organophosphorus compound;Pharmaceutical Intermediates;Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds |
| Mol File: | 762-04-9.mol |
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Diethyl phosphite Chemical Properties
| Melting point | -70 °C |
| Boiling point | 50-51 °C/2 mmHg (lit.) |
| density | 1.072 g/mL at 25 °C (lit.) |
| vapor pressure | 7hPa at 20℃ |
| refractive index | n20/D 1.407(lit.) |
| Fp | 180 °F |
| form | Liquid |
| color | Colorless |
| Specific Gravity | 1.072 |
| Water Solubility | miscible (hydrolysis) |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 605759 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, strong bases. May decompose on exposure to moisture. Combustible. |
| InChI | 1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3 |
| InChIKey | MJUJXFBTEFXVKU-UHFFFAOYSA-N |
| SMILES | [H]P(=O)(OCC)OCC |
| LogP | -0.15 |
| CAS DataBase Reference | 762-04-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphonic acid, diethyl ester(762-04-9) |
| EPA Substance Registry System | Diethyl phosphite (762-04-9) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-43 |
| Safety Statements | 26-36/37/39-37/39-28-27 |
| WGK Germany | 1 |
| RTECS | TG7875000 |
| F | 10-13-21 |
| TSCA | TSCA listed |
| HS Code | 29209014 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Dam. 1
Skin Sens. 1B |
| Hazardous Substances Data | 762-04-9(Hazardous Substances Data) |
Diethyl phosphite Usage And Synthesis
| Chemical Properties | colourless liquid |
| Uses | Diethyl phosphite (DEPI) is a versatile reactive intermediate used in the production of various phosphorus based substances. It may be used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides.
It may be used:- in the stereoselective synthesis of β-fluorinated alkylphosphonates
- Used in synthesis of homoallylic bromide
- Used in synthesis of series of carbazole-based α-aminophosphonates
- used as an extraction agent and phosphate intermediate.
- Used in synthesis of pesticides kitazine and phosethyl-Al as well as synthetic O, O-diethyl phosphoryl chloride.
- used for the synthesis of plasticizers, flame retardants, etc.
- Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX.
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| Uses | Diethyl phosphite is precursor used for the synthesis of various organophosphorus compounds. used to prepare the nickel chloride-diethyl phosphite system, efficient catalyst for the cross-coupling reaction between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. |
| Definition | ChEBI: A phosphonic ester that is the diethyl ester of phosphonic acid. |
| Synthesis Reference(s) | Synthetic Communications, 18, p. 665, 1988 DOI: 10.1080/00397918808077352 |
| Synthesis Reference(s) | Tetrahedron Letters, 29, p. 3327, 1988 DOI: 10.1016/0040-4039(88)85153-0 |
| General Description | Diethyl phosphite is reported to be chemical warfare agent (CWA) simulant, simulant for nerve agents sarin, soman, tabun, and VX. |
Diethyl phosphite Preparation Products And Raw materials
| Raw materials | Nitrogen-->Stirring vessel-->Oil pump |
| Preparation Products | (S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE-->Triethyl phosphite-->(R)-(+)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97%-->4,4'-Vinylenedipyridine-->Iprobenfos-->(S)-(-)-2,2'-BIS(DI-P-TOLYLPHOSPHINO)-1,1'-BINAPHTHYL-->(R)-(+)-TolBINAP-->Diphenylphosphine oxide-->Fosetyl aluminum-->Foscarnet sodium-->Ethephon-->Diethyl chlorophosphate-->FOSAMINE AMMONIUM-->ETHYLPHOSPHONIC ACID-->Diethyl 3,5-di-tert-butyl-4-hydroxybenzyl phosphate-->PARAOXON-->DIETHYL PHOSPHATE-->Optical brightener OB-1-->SODIUM O,O-DIETHYLTHIOPHOSPHATE |
