DIHYDROFISETIN CAS 20725-03-5

Introduction：Basic information about DIHYDROFISETIN CAS 20725-03-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

DIHYDROFISETIN Basic information

• Product Name: DIHYDROFISETIN
• Synonyms: DIHYDROFISETIN;3,3',4',7-TETRAHYDROXYFLAVANONE;3',4',7-TRIHYDROXYFLAVANONOL;2,3-DIHYDROFISETH;2,3-DIHYDROFISETIN;3,3,4,7-TETRAHYDROXYFLAVANONE 97%;3,7,3'',4''-TETRAHYDROXYFLAVANONE WITH HPLC;5-Deoxydihydrouercetin
• CAS: 20725-03-5
• MF: C15H12O6
• MW: 288.25
• EINECS: 243-989-6
• Product Categories: Dihydro-Flavanols
• Mol File: 20725-03-5.mol

DIHYDROFISETIN Chemical Properties

• Melting point: 216-217°C
• storage temp.: -20°C
• solubility: Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble
• form: A solid
• Boiling point: 644.2±55.0 °C(Predicted)
• density: 1.599±0.06 g/cm3(Predicted)
• pKa: 7.59±0.60(Predicted)
• color: White to off-white
• LogP: 0.870

Safety Information

• Risk Statements: 36/37/38
• Safety Statements: 26-36

DIHYDROFISETIN Usage And Synthesis

Uses

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].

Definition

ChEBI: A dihydroflavonol that is the 2,3-dihydro derivative of fisetin.

in vivo

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior^[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression^[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice^[1].