Introduction：Basic information about Dihydrostreptomycin sulfate CAS 5490-27-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dihydrostreptomycin sulfate Basic information
| Product Name: | Dihydrostreptomycin sulfate |
| Synonyms: | D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1?2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1?4)-N,N-bis(aminoiminomethyl)-, sulfate (2:3) (salt);dihydrostreptomycin solution;DIHYDROSTREPTOMYCINSULPHATE(INJ.);DIHYDROSTREPTOMYCINSULPHATE(ORAL);dihydrostreptomycin3/2sulfate;dihydro-streptomycisulfate(2:3)(salt);d-streptamine,o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1.fwdarw.2)-o;n’-bis(aminoiminomethyl)--3-c-(hydroxymethyl)-alpha-l-lyxofuranosyl-(1-4)- |
| CAS: | 5490-27-7 |
| MF: | C21H43N7O16S |
| MW: | 681.67 |
| EINECS: | 226-823-7 |
| Product Categories: | Agro-Products;Amines;PHARMACEUTICALS;A - KAntibiotics;Carbohydrates & Derivatives;Intermediates & Fine Chemicals;AminoglycosidesAntibiotics;Antibiotics A-FAntibiotics;Antibiotics by Application;AntimycobacterialAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisMore...Close...;Mechanism of Action;Antibacterial;Antibiotics A to;Spectrum of Activity |
| Mol File: | 5490-27-7.mol |
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Dihydrostreptomycin sulfate Chemical Properties
| alpha | D25 -88.5° (1% soln) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | H2O: 50 mg/mL, clear, faintly yellow |
| form | crystalline |
| color | white to light yellow |
| Water Solubility | Soluble in water |
| Merck | 13,3201 |
| BRN | 3894221 |
| Stability: | Hygroscopic |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | CZWJCQXZZJHHRH-YZTFXSNBSA-N |
| EPA Substance Registry System | D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt) (5490-27-7) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | WK2236000 |
| TSCA | TSCA listed |
| HS Code | 29412030 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral
Repr. 2 |
Dihydrostreptomycin sulfate Usage And Synthesis
| Chemical Properties | White Solid |
| Originator | Dihydrostrepto,MSD ,US,1948 |
| Uses | Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards. |
| Uses | As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops. |
| Uses | antibacterial, tuberculostatic |
| Manufacturing Process | Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate bycatalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction(Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), orby isolation from a fermentation process (Takeda). |
| Therapeutic Function | Antibiotic |
| Purification Methods | It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.] |
Dihydrostreptomycin sulfate Preparation Products And Raw materials
| Raw materials | Hydrogen-->Streptomycin sulfate |
