Dimethoxanate CAS 477-93-0
Introduction：Basic information about Dimethoxanate CAS 477-93-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dimethoxanate Basic information
| Product Name: | Dimethoxanate |
| Synonyms: | dimethoxanate;10h-phenothiazine-10-carboxylic acid 2-[2-(dimethylamino)ethoxy]ethyl ester;2-(2-dimethylaminoethoxy)ethyl phenothiazine-10-carboxylate;2-(2-dimethylaminoethyloxy)ethyl phenothiazine-10-carboxylate;phenothiazine-10-carboxylic acid 2-(2-dimethylaminoethyloxy)ethyl ester;Dimethoxanate USP/EP/BP |
| CAS: | 477-93-0 |
| MF: | C19H22N2O3S |
| MW: | 358.45 |
| EINECS: | 207-520-9 |
| Product Categories: | |
| Mol File: | 477-93-0.mol |
Dimethoxanate Chemical Properties
Safety Information
| Originator | Cothera,Ayerst,US,1957 |
| Definition | ChEBI: Dimethoxanate is a member of phenothiazines. |
| Manufacturing Process | 5.23 g of phenothiazine-10-carboxylic acid chloride were suspended in 8 g ofdimethylaminoethoxyethanol and heated, with stirring, under anhydrousconditions, first for 1 hour at a temperature of 50°-105°C, then for anotherhour at 108°-110°C. All the suspended acid chloride had dissolved after thefinal heating, and the solution was then allowed to cool slowly to 75°C over aperiod of one hour. Infrared examination of a sample showed that theesterification reaction was essentially complete after the second hour The reaction mixture was then poured on 1 liter of crushed ice, and the oilyprecipitate washed repeatedly by decantation with ice water. It was then takenup in 75 ml of benzene, and again washed repeatedly with water until a pH of8.2 in the washings indicated that substantially all of the excess β-dimethylaminoethoxyethanol had been removed. The benzene solution wasthen dried with anhydrous sodium sulfate, filtered, and the benzeneevaporated in a current of dry nitrogen gas. The residual dark oil constitutedthe desired basic ester. β-Dimethylaminoethoxyethyl phenothiazine-10-carboxylate. The basic ester may be dissolved in anhydrous ether and then precipitated byadding a slight excess of a solution of dry hydrogen chloride in ether and thehydrochloride salt may be isolated as an amorphous, glasslike product, whichcould be crystallized from anhydrous acetone or from methanol-ether. In thismanner there was obtained as a stable, crystalline, colorless substance β-dimethylaminoethoxyethyl phenothiazine-10-carboxylate hydrochloride, onesample of which melted at 161°-163°C with decomposition. |
| Therapeutic Function | Antitussive |
Dimethoxanate Preparation Products And Raw materials
| Raw materials | Hydrochloric acid-->2-[2-(Dimethylamino)ethoxy]ethanol |
