Dimethyl phosphite CAS 868-85-9
Introduction：Basic information about Dimethyl phosphite CAS 868-85-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Dimethyl phosphite Basic information
| Product Name: | Dimethyl phosphite |
| Synonyms: | (CH3O)2PHO;bis(hydroxymethyl)phosphineoxide;Dimethoxyphosphine oxide;dimethoxyphosphineoxide;Dimethyl acid phosphite;Dimethyl ester of phosphonic acid;dimethylacidphosphite;Dimethylester kyseliny fosforite |
| CAS: | 868-85-9 |
| MF: | C2H7O3P |
| MW: | 110.05 |
| EINECS: | 212-783-8 |
| Product Categories: | PETRO CATALYST;Building Blocks;Chemical Synthesis;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds;Pharmaceutical Intermediates;Organic Building Blocks;Organic Phosphates/Phosphites;Phosphorus Compounds |
| Mol File: | 868-85-9.mol |
Dimethyl phosphite Chemical Properties
| Boiling point | 170-171 °C(lit.) |
| density | 1.2 g/mL at 25 °C(lit.) |
| refractive index | n |
| Fp | 71 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Colorless liquid with a mildodor |
| Water Solubility | Soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1697490 |
| Stability: | Stable. Moisture sensitive. Incompatible with water, strong oxidizing agents, acid chlorides, strong bases. |
| InChI | InChI=1S/C2H7O3P/c1-4-6(3)5-2/h6H,1-2H3 |
| InChIKey | HZCDANOFLILNSA-UHFFFAOYSA-N |
| SMILES | P(=O)(OC)OC |
| CAS DataBase Reference | 868-85-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphonic acid, dimethyl ester(868-85-9) |
| IARC | 3 (Vol. 48, 71) 1999 |
| EPA Substance Registry System | Dimethyl phosphite (868-85-9) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 21-36-10-68-52/53-43-40 |
| Safety Statements | 26-36/37-61 |
| RIDADR | UN 3278 6.1/PG 3 |
| WGK Germany | 1 |
| RTECS | SZ7710000 |
| TSCA | TSCA listed |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29209013 |
| Hazardous Substances Data | 868-85-9(Hazardous Substances Data) |
| Chemical Properties | colourless liquid |
| Uses |
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| Uses | As a flame retardant on Nylon 6 fibers;intermediate in the production of pesticidesand herbicides; as a stabilizer in oil and plaster;an additive to lubricants |
| Definition | ChEBI: Dimethyl hydrogen phosphite is an organooxygen compound. |
| Application | DMP is a basic chemical which is used industrially as an intermediate. Because of its reactivity DMP participates in a large number of chemical reactions:
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| Synthesis Reference(s) | Canadian Journal of Chemistry, 34, p. 1819, 1956 DOI: 10.1139/v56-235 |
| Health Hazard | Dimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice. An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice. Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available. Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997). |
| Safety Profile | Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POx |
| Carcinogenicity | Dimethyl hydrogen phosphite was notmutagenic to several strains of Salmonellatyphimurium, but it did cause sister chromatidexchanges and chromosomal aberrations in theChinese hamster CHO line. An ACGIH threshold limit value (TLV)has not been established for dimethyl hydrogenphosphite. |
Dimethyl phosphite Preparation Products And Raw materials
| Raw materials | Dichloroethane |
| Preparation Products | Glyphosate-->Omethoate-->Trichlorfon-->2-Phosphonobutane-1,2,4-tricarboxylic acid-->Azamethiphos-->DIMETHYL PHOSPHOROCHLORIDATE-->ammonium O,O-dimethyl thiophosphate-->PHENYLPHOSPHONIC ACID DIMETHYL ESTER-->DIMETHYL-P-NITROPHENYLPHOSPHATE-->Dibenzoic thioanhydride-->sodium O,O-dimethyl thiophosphate-->DIISOBUTYL PHOSPHITE-->4-Bromophenyl methyl sulfone-->3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid |
