Divalproex sodium CAS 76584-70-8
Introduction：Basic information about Divalproex sodium CAS 76584-70-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Divalproex sodium Basic information
| Product Name: | Divalproex sodium |
| Synonyms: | DIVALPROEX SODIUM;SEMISODIUMVALPROATE;Dipropylacetic acid hemisodium salt;Sodium 2-propylpentanoate 2-propylpentanoic acid;Valproate semisodium;SODIUM DIVALPROATE;Divalproex Sodium (200 mg);Epival |
| CAS: | 76584-70-8 |
| MF: | C8H17NaO2 |
| MW: | 168.21 |
| EINECS: | 202-303-5 |
| Product Categories: | API;Depakote, Epival;Valproic acid Series;Inhibitors;Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 76584-70-8.mol |
Divalproex sodium Chemical Properties
| Melting point | 222 °C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C8H16O2.Na.H/c1-3-5-7(6-4-2)8(9)10;;/h7H,3-6H2,1-2H3,(H,9,10);; |
| InChIKey | WGNTXHWGJLKAFJ-UHFFFAOYSA-N |
| SMILES | C(C(=O)O)(CCC)CCC.[NaH] |
| CAS DataBase Reference | 76584-70-8(CAS DataBase Reference) |
Safety Information
| WGK Germany | WGK 3 |
| HS Code | 2915900000 |
| Storage Class | 11 - Combustible Solids |
| Description | Divalproex is a prodrug form of valproic acid that contains valproic acid and valproate sodium. Formulations containing divalproex exhibit delayed gastrointestinal absorption and are converted to valproic acid in the intestine, which reduces gastric irritation and nervous system side effects. Formulations containing divalproex are widely used for the treatment of seizures and bipolar disorder. |
| Chemical Properties | White Solid |
| Originator | Depakote,Abbott |
| Uses | Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder. |
| Uses | Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. In rare cases, it is also used as a treatment for major depressive disorder, and increasingly taken long-term for prevent |
| Uses | Anticonvulsant; Bipolar Agent |
| Definition | ChEBI: A mixture of valproic acid and its sodium salt in a 1:1 molar ratio. It is used for the management and treatment of seizure disorders, mania, and prophylactic treatment of migraine headache. |
| Manufacturing Process | Dipropyl acetic acid or valproic acid may be prepared the next way.Propylbromide is mixed with cyanacetic acid in the presence of sodiumethylate, made from absolute ethanol and sodium. By that prepared α,α-dipropylcyanacetic acid ethyl ester is saponified with equimolecular amountsof NaOH to give dipropylacetonitril. The desired dipropylacetic acid is producedby saponification of dipropylacetonitryl with aquatic NaOH. It is colorlessliquid. BP 219°-220°C. Sodium salt of this acid may be prepared by adding of equivalent of NaOH. |
| Brand name | Depakote (Abbott）. |
| Therapeutic Function | Anticonvulsant |
| Clinical Use | Treatment of manic episodes associated with bipolar disorder Migraine prophylaxis (unlicensed) |
| Drug interactions | Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly inhibitedby erythromycin; avoid with pivmecillinam;concentration reduced by carbapenems - avoid. Antidepressants: avoid with St John’s wort. Antiepileptics: concentration reduced bycarbamazepine; concentration of activecarbamazepine metabolite increased; increasedconcentration of lamotrigine, phenobarbital,rufinamide and possibly ethosuximide; sometimesreduces concentration of active metabolite ofoxcarbazepine; alters phenytoin concentration;phenytoin and phenobarbital reduce valproateconcentration; hyperammonaemia and CNS toxicitywith topiramate. Antipsychotics: increased neutropenia witholanzapine; possibly increases or decreasesconcentration of clozapine; possibly increasesquetiapine concentration. Ciclosporin: variable ciclosporin blood level response. Sodium oxybate: concentration of sodium oxybateincreased. Ulcer-healing drugs: metabolism inhibited bycimetidine, increased concentration. |
| Metabolism | Valproic acid is extensively metabolised in the liver, a largepart by glucuronidation (up to 60 %) and the rest by avariety of complex pathways (up to 45 %). It is excreted inthe urine almost entirely in the form of its metabolites;small amounts are excreted in faeces and expired air. |
| References | [1] MCGRAW D. Therapeutic drug monitoring with valproate-Why product selection is an important factor[J]. Mental Health Clinician, 2014, 19 1: 31-34. DOI: 10.9740/mhc.n186966 |
Divalproex sodium Preparation Products And Raw materials
| Raw materials | 1-Bromopropane-->Sodium |
