Introduction：Basic information about Domperidone maleate CAS 99497-03-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Domperidone maleate Basic information
| Product Name: | Domperidone maleate |
| Synonyms: | DOMPERIDONE MALEATE;5-chloro-1-[1-[3-(2-oxo-1,3-dihydrobenzoimidazol-1-yl)propyl]-4-piperidyl]-1,3-dihydrobenzoimidazol-2-one maleate;2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-, (Z)-2-butenedioate;E-Domperidone Maleate;6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;(E)-but-2-enedioic acid,6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one;Domperidone maleateQ: What is Domperidone maleate Q: What is the CAS Number of Domperidone maleate Q: What is the storage condition of Domperidone maleate;Domperidone Maleate IP/BP/Ph. Eur |
| CAS: | 99497-03-7 |
| MF: | C26H28ClN5O6 |
| MW: | 541.99 |
| EINECS: | 801-827-7 |
| Product Categories: | |
| Mol File: | 99497-03-7.mol |
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Domperidone maleate Chemical Properties
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Very slightly soluble in water, sparingly soluble in dimethylformamide, slightly soluble in methanol, very slightly soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to Off-White |
Safety Information
Domperidone maleate Usage And Synthesis
| Description | Domperidone maleate is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. |
| Chemical Properties | Domperidone maleate occurs as a white or almost white powder that exhibits polymorphism. It is very slightly soluble in water or alcohol. |
| Uses | Domperidone maleate (CAS# 99497-03-7); a form of Domperidone (D531100), a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. |
| Preparation | Domperidone was synthesized at Janssen Pharmaceutica in 1974 following their research on antipsychotic drugs. The present invention relates to synthesis of domperidone maleate. O-diaminobenzene is first cyclized and halogenated to form the first benzimidazolone intermediate; 1-carbethoxy-4-amino piperidine is halogenated, reduced, cyclized and hydrolyzed to form the second benzimidazolone intermediate; the two benzimidazolone intermediates are reacted to produce domperidone; and domperidone is finally reacted with maleic aicd to produce domperidone maleate.
https://patents.google.com/patent/CN1810805A/en |
| Indications | Domperidone may be useful for treatment of fescue toxicosis in pregnant mares or as a prokinetic or antiemetic agent in small animals. It has more effect on conditions with delayed gastric emptying than other GI hypomotility conditions. Via its effects on prolactin, domperidone may also be used to stimulate milk production in horses and small animals. Domperidone has been shown to increase plasma ACTH in horses with equine pituitary pars intermedia dysfunction (Equine Cushing’s) and may be useful in helping diagnose this condition. |
| Side effects | Because plasma prolactin levels may be increased, galactorrhea or gynecomastia may result. Injectable products (now withdrawn) have been associated with arrhythmias in human patients with heart disease or hypokalemia. Rarely, somnolence or dystonic reac- tions have occurred in people. |
Domperidone maleate Preparation Products And Raw materials
| Raw materials | o-Phenylenediamine-->Ethyl 4-amino-1-piperidinecarboxylate-->Domperidone |
