Introduction：Basic information about Doxifluridine CAS 3094-09-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Doxifluridine Basic information
| Product Name: | Doxifluridine |
| Synonyms: | 5’-deoxy-5-fluoro-uridin;Doxifluridine/5-Fluoro-5′-deoxyuridine;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone;Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine);5μdFUrd, Doxifluridine;5μdFUrd, 5-Fluoro-5μ-deoxyuridine |
| CAS: | 3094-09-5 |
| MF: | C9H11FN2O5 |
| MW: | 246.19 |
| EINECS: | 221-440-1 |
| Product Categories: | Heterocycles;API;Amines, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;FURTULON;Anti-cancer&immunity;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;API intermediates;Bases & Related Reagents;Nucleotides;Intermediates & Fine Chemicals;Pharmaceuticals;Pyrazines, Pyrimidines & Pyridazines;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents |
| Mol File: | 3094-09-5.mol |
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Doxifluridine Chemical Properties
| Melting point | 188-192 °C(lit.) |
| alpha | D25 +18.4° (c = 0.419 in water) |
| density | 1.3751 (estimate) |
| refractive index | 20 ° (C=1, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 7.4(at 25℃) |
| form | Solid |
| color | White |
| Merck | 14,3437 |
| Major Application | pharmaceutical small molecule |
| InChI | InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1 |
| InChIKey | ZWAOHEXOSAUJHY-ZIYNGMLESA-N |
| SMILES | C[C@H]1O[C@@H](N2C=C(F)C(=O)NC2=O)[C@H](O)[C@@H]1O |
| CAS DataBase Reference | 3094-09-5(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25 |
| WGK Germany | 2 |
| RTECS | YU7526000 |
| Hazard Note | Irritant |
| HazardClass | IRRITANT, IRRITANT-HARMFUL |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu) |
Doxifluridine Usage And Synthesis
| Description | Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it ismore potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers. |
| Chemical Properties | White Solid |
| Originator | Hoffmann-LaRoche (USA) |
| Uses | A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity |
| Uses | An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine |
| Uses | 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. |
| Uses | antineoplastic, pyrimidine antimetabolite |
| Definition | ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluororacil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. |
| Brand name | Furtulon |
| Biochem/physiol Actions | Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity. |
Doxifluridine Preparation Products And Raw materials
| Raw materials | Ethyl acetate-->Iodomethane-->p-Toluenesulfonic acid monohydrate-->Palladium carbon fine chemical catalyzer-->Triphenylantimony-->2,2-Dimethoxypropane |
