Doxylamine succinate CAS 562-10-7

Introduction：Basic information about Doxylamine succinate CAS 562-10-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Doxylamine succinate Basic information

• Product Name: Doxylamine succinate
• Synonyms: LABOTEST-BB LT00244822;DOXYLAMINE SUCCINATE;DOXYLAMINE SUCCINATE SALT;2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1;2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate;2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate;alsadorm;decapryn
• CAS: 562-10-7
• MF: C21H28N2O5
• MW: 388.46
• EINECS: 209-228-7
• Product Categories: API;DECAPRYN;Other APIs;Antagonists;Histaminergics;Neurotransmitters;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 562-10-7.mol

Doxylamine succinate Chemical Properties

• Melting point: 95-98?C
• Fp: 9℃
• storage temp.: 2-8°C
• solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
• form: Solid
• color: White to Off-White
• Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
• InChI: InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
• InChIKey: KBAUFVUYFNWQFM-UHFFFAOYSA-N
• SMILES: C(C)(OCCN(C)C)(C1=NC=CC=C1)C1C=CC=CC=1.C(C(=O)O)CC(=O)O
• LogP: 2.519 (est)
• CAS DataBase Reference: 562-10-7(CAS DataBase Reference)
• IARC: 3 (Vol. 79) 2001
• EPA Substance Registry System: Doxylamine succinate (1:1) (562-10-7)

Safety Information

• Hazard Codes: Xn,T,F
• Risk Statements: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
• Safety Statements: 26-36/37-45-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: US9275000
• HS Code: 2933399090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral STOT SE 3
• Toxicity: LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)

Doxylamine succinate Usage And Synthesis

Chemical Properties

white to light cream powder

Uses

H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.

Uses

antihistaminic, hypnotic

Uses

Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.

Definition

ChEBI: Doxylamine succinate is an organic molecular entity.

Brand name

Decapryn (Sanofi Aventis); Unisom (Pfizer).

General Description

The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.

General Description

White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.

Fire Hazard

Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.

Biochem/physiol Actions

H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.