Introduction：Basic information about Droxicam CAS 90101-16-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Droxicam Basic information
| Product Name: | Droxicam |
| Synonyms: | DROXICAM;5-Methyl-3-(2-pyridyl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide;5-Methyl-3-(pyridin-2-yl)-2H,5H-1,3-oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide;E-318;5-Methyl-3-(2-pyridinyl)-2H，5 H-1，3-oxaZino[5，6-c][1，2]benzothiazine-2，4(3H)-dione-6，6-dioxide;Dobenam;Droxar;E-3128 |
| CAS: | 90101-16-9 |
| MF: | C16H11N3O5S |
| MW: | 357.34 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 90101-16-9.mol |
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Droxicam Chemical Properties
| Melting point | 259-261° |
| Boiling point | 554.7±60.0 °C(Predicted) |
| density | 1.68±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 3.80±0.19(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| CAS DataBase Reference | 90101-16-9 |
Safety Information
| Toxicity | LD50 orally in male, female mice, and male, female rats: 6192, 8841, 1434, 1994 mg/kg (Soler, 1986) |
Droxicam Usage And Synthesis
| Description | Droxicam is an orally-active prodrug of piroxicam useful in the treatment ofspinal osteoarthritis. Although it has a pharmacological profile comparable topiroxicam, droxicam's experimental ulcerogenic effect is ten times less. In animalstudies droxicam is also reported to have analgesic and antipyretic activities, with nocardiovascular or respiratory effects. |
| Chemical Properties | Crystallized from acetone, melting point 259-261°C. Acute toxicity LD50 in male and female mice (mg/kg): 6192, 8841, 1434, 1994, oral. |
| Originator | Esteve (Spain) |
| Uses | Droxicam is a non-steroidal anti-inflammatory drug. |
| Definition | ChEBI: An organic heterotricyclic compound that is 2H,5H-[1,3]oxazino[5,6-c][1,2]benzothiazine-2,4(3H)-dione 6,6-dioxide substituted at positions 3 and 5 by pyridin-2-yl and methyl groups respetively. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. |
| Brand name | Ombolan |
| World Health Organization (WHO) | Droxicam is authorized to be marketed in many Europeancountries. Although droxicam is metabolized to piroxicam, it is considered that the risk of hepatic damage differs from that shown by other NSAIDs products,including piroxicam. |
Droxicam Preparation Products And Raw materials
| Raw materials | Polyethylene glycol dimethyl ether-->Phenyl carbamate |
