Eliapixant CAS 1948229-21-7

Introduction：Basic information about Eliapixant CAS 1948229-21-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Eliapixant Basic information

• Product Name: Eliapixant
• Synonyms: Benzamide, 3-(5-methyl-2-thiazolyl)-5-[[(3R)-tetrahydro-3-furanyl]oxy]-N-[(1R)-1-[2-(trifluoromethyl)-5-pyrimidinyl]ethyl]-;BAY 1817080;Eliapixant;Eliapixant（BAY 1817080）;Inhibitor,chronic,Eliapixant,cough,refractory,BAY-1817080,P2X Receptor,BAY1817080,P2X3,inhibit,P2XRs;Eliapixant, 10 mM in DMSO;3-(5-Methylthiazol-2-yl)-5-(((R)-tetrahydrofuran-3-yl)oxy)-N-((R)-1-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)benzamide
• CAS: 1948229-21-7
• MF: C22H21F3N4O3S
• MW: 478.49
• Mol File: 1948229-21-7.mol

Eliapixant Chemical Properties

• density: 1.360±0.06 g/cm3(Predicted)
• pka: 13.02±0.46(Predicted)
• form: Solid
• color: White to off-white

Eliapixant Usage And Synthesis

Uses

Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].

in vivo

Eliapixant can be used for the research of coughs and diabetes complications^[1].

IC 50

P2X3 Receptor

References

[1] Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561. DOI:10.3389/fphar.2021.653561
[2] Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240. DOI:10.1183/13993003.04240-2020