Introduction：Basic information about Exendin-3 (9-39) amide CAS 133514-43-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Exendin-3 (9-39) amide Basic information
| Product Name: | Exendin-3 (9-39) amide |
| Synonyms: | ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;H-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;EXENDIN 3 (9-39);EXENDIN-3 (9-39) AMIDE;EXENDIN (9-39);EXENDIN (9-39) AMIDE;EXENDIN [9-39] PEPTIDE;EXENDIN FRAGMENT 9-39 |
| CAS: | 133514-43-9 |
| MF: | C149H234N40O47S |
| MW: | 3369.76 |
| EINECS: | |
| Product Categories: | Peptide;GLP-1 Receptor LigandsObesity Research;Cytokines Growth Factors and Hormones (Obesity);ExendinPeptides for Cell Biology;Hormones;Obesity Peptides;Obesity Research;Other Obesity Research Products;Glucagon receptor and related |
| Mol File: | 133514-43-9.mol |
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Exendin-3 (9-39) amide Chemical Properties
| density | 1.51 |
| RTECS | LF2460000 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | H2O : 50 mg/mL (14.84 mM; Need ultrasonic) |
| form | Solid |
| color | Off-white to pale purple |
| Water Solubility | Soluble in water at 1mg/ml |
| Sequence | Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| InChIKey | WSEVKKHALHSUMB-UHFFFAOYSA-N |
Safety Information
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
Exendin-3 (9-39) amide Usage And Synthesis
| Description | Exendin-3 (9-39) amide is a truncated form of the exendin-4 peptide that acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R; Kd = 1.7 nM in CHL cells transfected with cloned human GLP-1). It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM). Exendin-3 (9-39) amide administration in the hypothalamus (10 and 100 μg, i.c.v.) reverses GLP-1 inhibition of feeding behavior in rats. |
| Uses | Biological probe. |
| Uses | Exendin-3 (9-39) is a potent and selective GLP-1 receptor antagonist. |
| General Description | Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of glucosedependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP. GLP-1, along with GIP, acts as a physiological incretin. |
| Biochem/physiol Actions | GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4. |
| storage | Store at -20°C |
Exendin-3 (9-39) amide Preparation Products And Raw materials
