| Description | Fenoxycarb is a carbamate insect growth regulator. Fenoxycarb is a yellow granular solid,broad-spectrum insect growth regulator, and non-neurotoxic carbamate. Fenoxycarb isalmost insoluble in water but soluble and very soluble in hexane, acetone, chloroform,diethyl ether, and methanol. Fenoxycarb is a general use pesticide (GUP), meaning theuser or the pesticide applicator does not need a licence. It is used to control a wide varietyof insect pests, such as fire ant bait and for flea and mosquito. It is also used for the controlof cockroaches, butterflies, moths, beetles, scale, and sucking insects on olives, vines,cottons, and fruits. It is also used to control these pests on stored products. As a growthregulator, fenoxycarb blocks the ability of an insect to change into the adult stage fromthe juvenile stage (metamorphosis). Fenoxycarb interferes with larval moulting, the periodicshedding or moulting of the old exoskeleton, and production of a new exoskeleton.Although fenoxycarb is a carbamate insecticide, it exhibits no anti-cholinesterase activityand is thus considered non-neurotoxic. It mimics the action of the juvenile hormones (JHs)on a number of physiological processes, such as moulting and reproduction in insects. |
| Chemical Properties | Fenoxycarb is a yellow granular solid, broad-spectrum insect growth regulator and nonneurotoxic carbamate. Fenoxycarb is almost insoluble in water, but soluble and very soluble in hexane, acetone, chloroform, diethyl ether, and methanol. Fenoxycarb is a GUP, meaning the user or the pesticide applicator does not need a license. It is used to control a wide variety of insect pests, as a fi re ant bait and for fl ea and mosquito control. It is also used for the control of cockroaches, butterfl ies, moths, beetles, scale, and sucking insects, pests of stored products. As a growth regulator, fenoxycarb blocks the ability of an insect to change into the adult stage from the juvenile stage (metamorphosis). Fenoxycarb interferes with larval molting, the periodic shedding or molting of the old exoskeleton and production of a new exoskeleton. Although fenoxycarb is a carbamate insecticide, it exhibits no anticholinesterase activity and is thus considered non-neurotoxic. It is useful for the control of fi re ants, fl eas, mosquitoes, cockroaches, moths, scale insects, and insects attacking vines, olives, cotton, and fruit. It is also used to control these pests on stored products, and is often formulated as a grit or corncob bait. It mimics the action of the juvenile hormones (JH) on a number of physiological processes, such as molting and reproduction in insects. |
| Uses | Fenoxycarb is mainly used to control Lepidoptera, scale insectsand suckers on fruit, cotton, olives, vines and ornamentals. It is used tocontrol Coleoptera and Lepidoptera in stored products, and cockroaches,fleas, mosquito larvae and fire ants in public health situations. |
| Definition | ChEBI: Fenoxycarb is a carbamate ester that is the O-ethyl carbamate of 2-(4-phenoxyphenoxy)ethylamine. It has a role as a juvenile hormone mimic, an environmental contaminant, a xenobiotic and an insecticide. It is an aromatic ether and a carbamate ester. It is functionally related to a 4-phenoxyphenol. |
| Health Hazard | Fenoxycarb is practically non-toxic to mammals after oral ingestion. The oral LD50 for rats is greater than 10,000 mg/kg and the dermal LD50 for rats is greater than 2,000 mg/ kg. Direct application of fenoxycarb on the skin of laboratory rats caused labored breathing and diarrhea in animals. Although fenoxycarb does not irritate the skin, it is an eye irritant. The liver is the primary organ affected by fenoxycarb in long-term animal studies. Prolonged period of oral exposures to rats and dogs with very low doses of fenoxycarb caused no health effects in the animals, while high concentrations caused adverse effects to the liver of rats, mice, and dogs. Reports on the teratogenicity and mutagenicity of fenoxycarb are not available in the literature. |
| Metabolic pathway | When the insect larvae of tobacco budworm are fedwith 14C-fenoxycarb, at the time of gut purge, thewhole of the radio-labeled material is excreted. Themain metabolites of fenoxycarb are identified andshow hydroxylation of the aromatic rings which makesthe excretion easier. Cleavage of the molecule to givecarboxylic acid metabolites confirms the hypothesisthat the fenoxycarb is not cleaved by esterase. |
| Degradation | Solutions of [14C-1,4-phenoxy]fenoxycarb in aqueous buffers (pH 3, 7, 9)were maintained at 35 °C for 70 days. The compound was stable overthis period (PSD, 1997). In a study to US EPA guidelines, a solution of[14C-1,4-phenoxy]fenoxycarb in sterile buffer at pH 7 and at 25 °C wasirradiated with a xenon arc lamp. Light of wavelength less than 290 nmwas filtered out. Irradiation was equivalent to one year of average middaysunlight at 40-50°N. Additional tests were done using acetone as aphotosensitiser. Samples were analysed using LSC and HPLC methods.Little 14CO2 was evolved and 80 and 40% of the parent fenoxycarbdegraded within 210 minutes in the sensitised and unsensitised samples,respectively. Seven photoproducts were identified from the unsensitisedsamples but only the phenol (2) was formed (see Scheme 1) in appreciableamount (12.3% of applied radioactivity after 6 hours) (PSD, 1997). |
