Flufenoxuron CAS 101463-69-8

Introduction：Basic information about Flufenoxuron CAS 101463-69-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Flufenoxuron Basic information

• Product Name: Flufenoxuron
• Synonyms: N-[4-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-FLUOROPHENYLAMINOCARBONYL]-2,6-DIFLUORO-BENZAMIDE;CASCADE;FLUFENOXURON;N-((4-(2-chloro-4-(triluoromethyl)phenoxy))amino)carbonyl-2,6-difluorobenzamide;FLUFENOXURON PESTANAL, 250 MG;flufenoxoron;(1-(4-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-fluorophenyl)-3-(2,6-difluorobenzoyl)urea;Benzamide, N-4-2-chloro-4-(trifluoromethyl)phenoxy-2-fluorophenylaminocarbonyl-2,6-difluoro-
• CAS: 101463-69-8
• MF: C21H11ClF6N2O3
• MW: 488.77
• EINECS: 417-680-3
• Mol File: 101463-69-8.mol

Flufenoxuron Chemical Properties

• Melting point: 169-172° (dec)
• density: 1.5123 (estimate)
• vapor pressure: 6.52 x l0^-12 Pa (20 °C)
• storage temp.: 0-6°C
• solubility: Benzene (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Sparingly)
• pka: 8.68±0.46(Predicted)
• Water Solubility: 4 x l0^-6 mg l^-1(25 °C)
• form: Solid
• color: Off-White to Light Beige
• BRN: 8398323
• Major Application: agriculture environmental
• InChI: 1S/C21H11ClF6N2O3/c22-12-8-10(21(26,27)28)4-7-17(12)33-11-5-6-16(15(25)9-11)29-20(32)30-19(31)18-13(23)2-1-3-14(18)24/h1-9H,(H2,29,30,31,32)
• InChIKey: RYLHNOVXKPXDIP-UHFFFAOYSA-N
• SMILES: Fc1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1NC(=O)NC(=O)c3c(F)cccc3F
• CAS DataBase Reference: 101463-69-8(CAS DataBase Reference)
• EPA Substance Registry System: Flufenoxuron (101463-69-8)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 20
• Safety Statements: 22
• RIDADR: 3077
• WGK Germany: 2
• RTECS: CV2474500
• HazardClass: 9
• PackingGroup: III
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Acute 1 Aquatic Chronic 1 Lact.
• Hazardous Substances Data: 101463-69-8(Hazardous Substances Data)
• Toxicity: LD50 in rats (mg/kg): >3000 orally; >2000 percutaneously (Anderson)

Flufenoxuron Usage And Synthesis

Uses

Flufenoxuron is an known insecticide and acts as an insect growth regulator by inhibiting chitin synthesis.

Uses

Flufenoxuron is used for the control of many phytophagous mites(Aculus, Brevipalpus, Pananychus, Phyllocoptuuta, Tetuanychus, spp) andinsect pests on pome fruit, vines, citrus, tea, cotton, maize, vegetables andornamentals. It is also used as a public hygiene insecticide.

Definition

ChEBI: Flufenoxuron is a benzoylurea insecticide, a member of monochlorobenzenes, a member of (trifluoromethyl)benzenes, a member of monofluorobenzenes and a difluorobenzene. It has a role as a mite growth regulator. It derives from a diphenyl ether.

Metabolic pathway

Information on the metabolism of flufenoxuron is avilable in a PesticidesSafety Directorate review of its use as a public hygiene insecticide (PSD).

Degradation

The DT₅₀ of flufenoxuron (25 °C) was 267 days at pH 7,206 days at pH 5and 36.7 days at pH 9 (PM).
Flufenoxuron underwent photodegradation to form 2,6-difluorobenzamide(2), the urea derivative 3 and the 4-aminodiphenyl ether 4 inaqueous solution under natural sunlight in the UK (PSD, 1995).

Mode of action

Flufenoxuron acts in a similar manner to diflubenzuron, reducing chitin incorporation in the cuticJe (Clarke and Jewess 1990). It has cuticular and stomach action. It has ovo-Iarvicidal activity. Treated adults lay non-viable eggs (Tomlin 1995).

Flufenoxuron Preparation Products And Raw materials

• Raw materials: Oxalyl chloride-->PHOSGENE-->CHLOROETHANE-->Chlorfluazuron-->3,4-Dichlorobenzotrifluoride-->2,6-Difluorobenzamide-->2-Fluoroaniline-->2,6-Difluorobenzoyl isocyanate-->4-Amino-3-fluorophenol
• Preparation Products: Hexaflumuron