Fluorene CAS 86-73-7
Introduction：Basic information about Fluorene CAS 86-73-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Fluorene Basic information
| Product Name: | Fluorene |
| Synonyms: | Industrial fluorene;Fluorene≥ 99% (HPLC);O-BIPHENYLENEMETHANE;alpha-diphenylenemethane;FLUORENE,REAGENT;Fluorene 98%;2,2’-Methylemebiphemyl;METHYLENEBIPHENYL |
| CAS: | 86-73-7 |
| MF: | C13H10 |
| MW: | 166.22 |
| EINECS: | 201-695-5 |
| Product Categories: | Analytical Standards;AromaticsVolatiles/ Semivolatiles;Chemical Class;FA - FLChemical Class;Hydrocarbons;Neats;Highly Purified Reagents;Other Categories;Zone Refined Products;Fluorene series;Alpha Sort;Arenes;Building Blocks;Organic Building Blocks;Pharmaceutical Intermediates;Fluorene Derivatives;Fluorenes, Flurenones;Electronic Chemicals;Building Blocks;Fluorene;Organoborons;Color Former & Related Compounds;Fluorenes;Fluorenes & Fluorenones;Functional Materials;Sensitizer;E-LAlphabetic;F;FA - FL;Volatiles/ Semivolatiles;Aromatics;OLED materials,pharm chemical,electronic;PAH;1 |
| Mol File: | 86-73-7.mol |
Fluorene Chemical Properties
| Melting point | 111-114 °C (lit.) |
| Boiling point | 298 °C (lit.) |
| density | 1.2 |
| vapor pressure | 13 hPa (146 °C) |
| refractive index | 1.6470 |
| Fp | 151 °C |
| storage temp. | room temp |
| solubility | 0.002g/l insoluble |
| form | Crystalline Powder |
| pka | >15 (Christensen et al., 1975) |
| color | Almost white to light brown |
| Water Solubility | insoluble |
| Merck | 14,4155 |
| BRN | 1363491 |
| Henry's Law Constant | 1.89(x 10-5 atm?m3/mol) at 4 °C, 12.5 at 25 °C (dynamic equilibrium method, Bamford et al., 1999) |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Major Application | environmental |
| InChI | 1S/C13H10/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)12/h1-8H,9H2 |
| InChIKey | NIHNNTQXNPWCJQ-UHFFFAOYSA-N |
| SMILES | C1c2ccccc2-c3ccccc13 |
| LogP | 4.164 |
| CAS DataBase Reference | 86-73-7(CAS DataBase Reference) |
| IARC | 3 (Vol. Sup 7, 92) 2010 |
| NIST Chemistry Reference | Fluorene(86-73-7) |
| EPA Substance Registry System | Fluorene (86-73-7) |
Safety Information
| Hazard Codes | N,T,F,Xn,Xi |
| Risk Statements | 50/53-39/23/24/25-23/24/25-11-67-65-38-36/38-36/37/38-52/53-20 |
| Safety Statements | 60-61-24/25-45-36/37-16-7-62-33-24-22-36/37/39-27-26-25-9 |
| RIDADR | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | LL5670000 |
| Hazard Note | Harmful |
| TSCA | TSCA listed |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29029080 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
| Hazardous Substances Data | 86-73-7(Hazardous Substances Data) |
| Toxicity | Drinking water standard: No MCLGs or MCLs have been proposed, however, a DWEL of 1mg/L was recommended (U.S. EPA, 2000). |
| Description | Fluorene, when pure, is found as dazzlingwhite flakes or small, crystalline plates. It is fluorescentwhen impure. Polynuclear aromatic hydrocarbons (PAHs)are compounds containing multiple benzene rings and arealso called polycyclic aromatic hydrocarbons. Molecularweight=166.23; Boiling point=293C (decomposes);Freezing/Melting point=116-117C; Flash point=151C. Hazard Identification (based on NFPA-704 MRating System): Health 1, Flammability 1, Reactivity 0.Insoluble in water. |
| Chemical Properties | white crystals |
| Chemical Properties | Fluorene, when pure, is found as dazzling white flakes or small, crystalline plates. It is fluorescentwhen impure. Polycyclic aromatic hydrocarbons (PAHs)are compounds containing multiple benzene rings and arealso called polynuclear aromatic hydrocarbons. |
| Physical properties | Small white leaflets or crystalline flakes from ethanol. Fluorescent when impure. |
| Uses | Polycyclic aromatic hydrocarbons as micropollutants. |
| Uses | Fluorene was used study the extraction of specific, semiconducting single-wall carbon nanotubes (SWCNTs). |
| Definition | ChEBI: An ortho-fused tricyclic hydrocarbon that is a major component of fossil fuels and their derivatives |
| Synthesis Reference(s) | Journal of the American Chemical Society, 73, p. 2656, 1951 DOI: 10.1021/ja01150a069 Synthetic Communications, 26, p. 1467, 1996 DOI: 10.1080/00397919608003512 The Journal of Organic Chemistry, 37, p. 1273, 1972 DOI: 10.1021/jo00973a049 |
| General Description | White leaflets. Sublimes easily under a vacuum. Fluorescent when impure. |
| Air & Water Reactions | Insoluble in water. |
| Reactivity Profile | Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as Fluorene, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction. |
| Hazard | Questionable carcinogen. |
| Health Hazard | Acute toxicity in animals is very low. AnLD50 (intraperitoneal) in mice is 2000 mg/kg.Carcinogenicity of this compound in animalsis not well established. It tested negative in ahistidine reversion–Ames test. |
| Health Hazard | ACUTE/CHRONIC HAZARDS: Fire hazards: Slight, when exposed to heat or flame. |
| Potential Exposure | Fluorene is used in resins, dyes, and isa chemical intermediate. |
| First aid | If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit. |
| Source | Fluorene was detected in groundwater beneath a former coal gasification plant in Seattle,WA at a concentration of 140 μg/L (ASTR, 1995). Present in diesel fuel and corresponding aqueous phase (distilled water) at concentrations of 350 to 900 mg/L and 12 to 26 g/L,respectively (Lee et al., 1992). Schauer et al. (1999) reported fluorene in diesel fuel at aconcentration of 52 g/g and in a diesel-powered medium-duty truck exhaust at an emission rate of34.6 g/km. Diesel fuel obtained from a service station in Schlieren, Switzerland contained fluoreneat an estimated concentration of 170 mg/L (Schluep et al., 2001). Based on laboratory analysis of 7 coal tar samples, fluorene concentrations ranged from 1,100 to12,000 ppm (EPRI, 1990). Lao et al. (1975) reported a fluorene concentration of 27.39 g/kg in acoal tar sample. Detected in 1-yr aged coal tar film and bulk coal tar at an identical concentrationof 4,400 mg/kg (Nelson et al., 1996). A high-temperature coal tar contained fluorene at an averageconcentration of 0.64 wt % (McNeil, 1983). Identified in high-temperature coal tar pitches atconcentrations ranging from 800 to 4,000 mg/kg (Arrendale and Rogers, 1981). Lee et al. (1992a)equilibrated 8 coal tars with distilled water at 25 °C. The maximum concentration of fluoreneobserved in the aqueous phase was 0.3 mg/L. Fluorene was detected in asphalt fumes at an average concentration of 34.95 ng/m3 (Wang et al.,2001). Nine commercially available creosote samples contained fluorene at concentrations rangingfrom 19,000 to 73,000 mg/kg (Kohler et al., 2000). Thomas and Delfino (1991) equilibrated contaminant-free groundwater collected fromGainesville, FL with individual fractions of three individual petroleum products at 24–25 °C for24 h. The aqueous phase was analyzed for organic compounds via U.S. EPA approved test method625. Average fluorene concentrations reported in water-soluble fractions of unleaded gasoline,kerosene, and diesel fuel were 1, 3, and 10 μg/L, respectively. Fluorene was detected in soot generated from underventilated combustion of natural gas dopedwith toluene (3 mole %) (Tolocka and Miller, 1995). Schauer et al. (2001) measured organic compound emission rates for volatile organiccompounds, gas-phase semi-volatile organic compounds, and particle-phase organic compoundsfrom the residential (fireplace) combustion of pine, oak, and eucalyptus. The gas-phase emissionrates of fluorene were 4.44 mg/kg of pine burned, 3.83 mg/kg of oak burned, and 2.613 mg/kg ofeucalyptus burned. California Phase II reformulated gasoline contained fluorene at a concentration of 4.35 mg/kg.Gas-phase tailpipe emission rates from gasoline-powered automobiles with and without catalyticconverters were 9.72 and 358 μg/km, respectively (Schauer et al., 2002). Under atmospheric conditions, a low rank coal (0.5–1 mm particle size) from Spain was burnedin a fluidized bed reactor at seven different temperatures (50 °C increments), beginning at 650 °C.The combustion experiment was also conducted at different amounts of excess oxygen (5 to 40%)and different flow rates (700 to 1,100 L/h). At 20% excess oxygen and a flow rate of 860 L/h, theamount of fluorine emitted ranged from 850.7 ng/kg at 950 °C to 3,632.8 ng/kg at 750 °C. Thegreatest amount of PAHs emitted were observed at 750 °C (Mastral et al., 1999). In one study, fluorene comprised about 7.6% of polyaromatic hydrocarbons in creosote (Grifollet al., 1995). Identified as an impurity in commcerially available acenaphthene (Marciniak, 2002). Typical concentration of fluorene in a heavy pyrolysis oil is 1.6 wt % (Chevron Phillips, May2003). |
| Environmental fate | Biological. Fluorene was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. Significant biodegradation with gradual adaptation was observed.At concentrations of 5 and 10 mg/L, biodegradation yields at the end of 4 wk of incubation were77 and 45%, respectively (Tabak et al., 1981). Photolytic. Fluorene reacts with photochemically produced OH radicals in the atmosphere. Theatmospheric half-life was estimated to range from 6.81 to 68.1 h (Atkinson, 1987). Behymer andHites (1985) determined the effect of different substrates on the rate of photooxidation of fluorene(25 μg/g substrate) using a rotary photoreactor. The photolytic half-lives of fluorene using silicagel, alumina, and fly ash were 110, 62, and 37 h, respectively. Gas-phase reaction rate constantsfor OH radicals, NO3 radicals, and ozone at 24 °C were 1.6 x 10-11, 3.5 x 10-15, and <2 x 10-19 incm3/molecule?sec, respectively (Kwok et al., 1997). Chemical/Physical. Oxidation by ozone to fluorenone has been reported (Nikolaou, 1984).Chlorination of fluorene in polluted humus poor lake water gave a chlorinated derivativetentatively identified as 2-chlorofluorene (Johnsen et al., 1989). This compound was alsoidentified as a chlorination product of fluorene at low pH (<4) (Oyler et al., 1983). It wassuggested that the chlorination of fluorene in tap water accounted for the presence ofchlorofluorene (Shiraishi et al., 1985). |
| storage | Color Code—Green: General storage may be used.Prior to working with this chemical you should be trainedon its proper handling and storage. Store in tightly closedcontainers in a cool, well-ventilated area away from oxidizers and source of ignition. |
| Shipping | UN3077 Environmentally hazardous substances,solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required. |
| Purification Methods | Purify fluorene by chromatography of CCl4 or pet ether (b 40-60o) solution on alumina, with *benzene as eluent. Crystallise it from 95% EtOH, 90% acetic acid and again from EtOH. Crystallisation using glacial acetic acid retains an impurity which is removed by partial mercuration and precipitation with LiBr [Brown et al. J Am Chem Soc 84 1229 1962]. It has also been crystallised from hexane, or *benzene/EtOH, distilled under vacuum and purified by zone refining. [Gorman et al. J Am Chem Soc 107 4404 1985, Beilstein 5 IV 2142.] |
| Incompatibilities | Incompatible with oxidizers (chlorates,nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases,strong acids, oxoacids, epoxides. Compound can react exo thermically with bases and with diazo compounds.Substitution at the benzene nucleus occurs by halogenation(acid catalyst), nitration, sulfonation, and the Friedel Craftsreaction. |
| Toxics Screening Level | The current ITSL for Fluorene is 140 μg/m3 , with annual averaging time (AT). |
| Waste Disposal | Persons in charge of vesselsor facilities are required to notify the National ResponseCenter (NRC) immediately when there is a release of thisdesignated hazardous substance, in an amount equal to orgreater than its RQ listed above. The toll free number ofthe NRC is (800) 424-8802; In the Washington D.C. metro politan area call (202) 426-2675. The rule for determiningwhen notification is required is stated in 40 CFR 302.4(Section IV. D.3.b). |
Fluorene Preparation Products And Raw materials
| Raw materials | Polishing oil-->Column plate-->Benzo[a]pyrene |
| Preparation Products | 2-Bromo-9,9-dimethylfluorene-->2-Amino-9,9-dimethylfluorene-->Irbesartan-->2-Nitrofluorene-->Fmoc-Tyr(tBu)-OH-->2-Acetylfluorene-->FMOC-O-tert-Butyl-L-serine-->N-FMOC-L-aspartic acid 4-t-butyl ester-->FMOC-O-tert-Butyl-L-threonine-->Nalpha-FMOC-L-Asparagine-->Fmoc-L-glutamic acid 5-tert-butyl ester-->4-bromo-9,9'-Spirobi[9H-fluorene-->2,7-Dibromo-9,9'-spiro-bifluorene-->2-Methyl-1,3-cyclopentanedione-->2,7-Dichlorofluorene-->3-Bromo-9H-fluorene-->9-(2-BROMOETHYL)-9H-FLUORENE |
