Gestodene CAS 60282-87-3
Introduction：Basic information about Gestodene CAS 60282-87-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Gestodene Basic information
| Product Name: | Gestodene |
| Synonyms: | (8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14-decahydrocyclopenta[a]phenanthren-3-one;17-alpha-Ethynyl-13-ethyl-17-beta-hydroxy-4,15-gonadien-3-one;18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17-alpha);(17R)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one;15-ethyl-14-ethynyl-14-hydroxytetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,12-dien-5-one;Gestodene Methyl analogue: 17alpha-(1-Propyn-1-yl)-17a-hydroxy-18-Methyl-4,15-estradien-3-one;(8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-17-hydroxy-6,7,8,9,10,11,12,13,14,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;(8R,9S,10R,13S,14S,17S)-13-ethyl-17-ethynyl-17-hydroxy-1,7,8,10,11,12,13,17-octahydro-2H-cyclopenta[a]phenanthren-3(6H,9H,14H)-one |
| CAS: | 60282-87-3 |
| MF: | C21H26O2 |
| MW: | 310.43 |
| EINECS: | 262-145-8 |
| Product Categories: | Steroid and Hormone;Hormone Drugs;Miscellaneous Biochemicals;Hormone;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
| Mol File: | 60282-87-3.mol |
Gestodene Chemical Properties
| Melting point | 190-192°C |
| Boiling point | 462.7±45.0 °C(Predicted) |
| density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: >20mg/mL |
| pka | 12.16±0.40(Predicted) |
| form | powder |
| color | white to off-white |
| Optical Rotation | [α]/D -175 to -195° (DCM) |
| λmax | 240nm(MeOH)(lit.) |
| Merck | 14,4413 |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C21H26O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,10,12-13,16-19,23H,3,5-9,11H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1 |
| InChIKey | SIGSPDASOTUPFS-XUDSTZEESA-N |
| SMILES | C1C[C@]2([H])[C@@]3([H])CC[C@]4(CC)[C@@](C#C)(O)C=C[C@@]4([H])[C@]3([H])CCC2=CC1=O |
| CAS DataBase Reference | 60282-87-3(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 62 |
| Safety Statements | 36/37-24/25 |
| WGK Germany | 3 |
| RTECS | JF7956000 |
| HS Code | 29144000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Repr. 2 |
| Hazardous Substances Data | 60282-87-3(Hazardous Substances Data) |
| Description | Gestodene is a progestogen, recently launched in combination with ethinyl estradiol as anoral contraceptive.Gestodene is a steroid. It has a role as an estrogen.Gestodene, one of three new gonane progestins, is the most potent on a per weight basis in regard to progestational effects and has little or no estrogenic effect. In in vivo animal studies, gestodene also has less androgenic activity compared with progestins found in older combination oral contraceptive formulations. |
| Chemical Properties | White Crystalline Solid |
| Originator | Schering AG (W. Germany) |
| Uses | Gestodene is an orally active gestogen with a progesterone-like profile of activity. Gestodene is used in combination with estrogen as an oral contraceptive. |
| Uses | Orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive. |
| Uses | Estrogens and progestins are female hormones. They are produced by the body and are necessary for the normal sexual development of the female and for the regulation of the menstrual cycle during the childbearing years. Gestodene is a progestogen hormonal |
| Definition | ChEBI: Gestodene is a steroid. It has a role as an estrogen. |
| Brand name | Femodene |
Gestodene Preparation Products And Raw materials
| Raw materials | N,N-Dimethylformamide-->Methanesulfonyl chloride-->Potassium chloride-->Ferrous sulfate heptahydrate-->Sodium nitrate-->Potassium Phosphate Monobasic-->Argon-->4-Methyl-2-pentanone-->Acetylacetone-->MAIZE POWDER MA 1.0 IRMM CERTIFIED RE-F-->18,19-Dinorpregna-4,15-dien-20-yn-3-one, 13-ethyl-17-hydroxy-, cyclic 1,2-ethanediyl mercaptole, (17α)- (9CI)-->Gestodene Impurity 1-->13BETA-ETHYL-15A-HYDROXY-18-NORANDROST-4-ENE-3,17-DIONE-->D-Ethylgonendione-->Bromoethane-->ETHYNYLMAGNESIUM BROMIDE-->Acetylene |
