Ginsenoside Rf CAS 52286-58-5

Introduction：Basic information about Ginsenoside Rf CAS 52286-58-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Ginsenoside Rf Basic information

• Product Name: Ginsenoside Rf
• Synonyms: GINSENOSIDE RF;PANAXOSIDE RF;GINSENOSIDE Rf hplc;GINSENOSIDE RF WITH HPLC;droxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-;β-D-Glucopyranoside, (3β,6α,12β)-3,12,20-trihy;(3β,6α,12β)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside;(20S)-6α-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyloxy)-5α-dammara-24-ene-3β,12β,20-triol
• CAS: 52286-58-5
• MF: C42H72O14
• MW: 801.02
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Saponins;Ginsenoside series
• Mol File: 52286-58-5.mol

Ginsenoside Rf Chemical Properties

• Melting point: 197～198℃
• Boiling point: 912.3±65.0 °C(Predicted)
• density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Methanol (Slightly), Pyridine (Slightly)
• form: Solid
• pka: 12.85±0.70(Predicted)
• color: White to Off-White
• Major Application: food and beverages
• InChIKey: UZIOUZHBUYLDHW-CGJOLZHFNA-N
• LogP: 3.560 (est)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 2-45-24/25
• WGK Germany: 3
• RTECS: LY9536900
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral

Ginsenoside Rf Usage And Synthesis

Chemical Properties

White to off-white solid

Uses

Ginsenoside Rf is an anti-arthritic agent, attenuating collagen-induced arthritis in mice.

Definition

ChEBI: Ginsenoside Rf is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy group at position 6 has been converted to the corresponding beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an apoptosis inducer and an antineoplastic agent. It is a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a beta-D-glucoside, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid, a 20-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.

in vivo

Since inhibition of Ca²⁺ channels in sensory neurons contributes to antinociception by opioids, analgesic actions of Ginsenoside Rf are tested. Dose-dependent antinociception is found by systemic administration of Ginsenoside Rf in mice using two separate assays of tonic pain: in the acetic acid abdominal constriction test, the ED₅₀ is 56±9 mg/kg, a concentration similar to those reported for aspirin and acetaminophen in the same assay; in the tonic phase of the biphasic formalin test, the ED₅₀ is 129±32 mg/kg^[2].

IC 50

N-type calcium channel