Introduction：Basic information about GLYCINE ANHYDRIDE CAS 106-57-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
GLYCINE ANHYDRIDE Basic information
| Product Name: | GLYCINE ANHYDRIDE |
| Synonyms: | PIPERAZINE-2,5-DIONE;Glycine EP Impurity B;Oxiracetam-1;2,5-Dioxopiperazin;2,5-Dioxopiperazine lactam;2,5-Piperazindion;alpha,gamma-Diacipiperazine;Cyclic(glycylglycyl) |
| CAS: | 106-57-0 |
| MF: | C4H6N2O2 |
| MW: | 114.1 |
| EINECS: | 203-411-5 |
| Product Categories: | |
| Mol File: | 106-57-0.mol |
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GLYCINE ANHYDRIDE Chemical Properties
| Melting point | >300 °C (lit.) |
| Boiling point | 213.59°C (rough estimate) |
| density | 1.3565 (rough estimate) |
| refractive index | 1.4487 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | 142g/l |
| pka | 12.88±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to slightly yellow |
| Water Solubility | Soluble in water (142mg/L). |
| Merck | 14,7466 |
| BRN | 112112 |
| InChI | 1S/C4H6N2O2/c7-3-1-5-4(8)2-6-3/h1-2H2,(H,5,8)(H,6,7) |
| InChIKey | BXRNXXXXHLBUKK-UHFFFAOYSA-N |
| SMILES | N1CC(=O)NCC1=O |
| CAS DataBase Reference | 106-57-0(CAS DataBase Reference) |
| EPA Substance Registry System | 2,5-Piperazinedione (106-57-0) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | TL6325250 |
| TSCA | TSCA listed |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
GLYCINE ANHYDRIDE Usage And Synthesis
| Chemical Properties | white to slightly yellow crystalline powder |
| Uses | 2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis. |
| Definition | ChEBI: A cyclic peptide that is piperazine in which the hydrogens at positions 2 and 5 are replaced by oxo groups. |
| Synthesis Reference(s) | Journal of the American Chemical Society, 87, p. 4646, 1965 DOI: 10.1021/ja00948a047 |
| Purification Methods | Recrystallise glycine anhydride from H2O (plates) and it can be sublimed (slowly) at 260o or at 140-170o/0.5mm. The dihydrochloride has m 129-130o and is prepared by dissolving it in conc HCl and adding EtOH to crystallisation point; dry it in a vacuum. The bis-1-naphthylurethane has m 232o(dec), and the diperchlorate has m 117o (hygroscopic). [MS: Johnstone J Chem Soc, Perkin Trans 1 1297 1975, NMR: Blaha & Samek Collect Czech Chem Commun 32 3780 1967, Sauborn J Phys Chem 36 179 1932, Corey J Am Chem Soc 60 1599 1938, Beilstein 24 IV 1070.] |
GLYCINE ANHYDRIDE Preparation Products And Raw materials
| Raw materials | 1,4-Dibromo-piperazine-2,5-dione-->TRANS-1,2-DIBROMOCYCLOHEXANE-->3-BROMOCYCLOHEXENE |
| Preparation Products | 4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID-->N,N'-Dimethylpiperazine-->Pyrazine, tetrachloro--->2,3,5-Piperazinetrione |
