Griffipavixanthone CAS 219649-95-3

Introduction：Basic information about Griffipavixanthone CAS 219649-95-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Griffipavixanthone Basic information

• Product Name: Griffipavixanthone
• Synonyms: Griffipavixanthone;Indeno[1,2-a]xanthen-13(8H)-one, 8a,9,10,12a-tetrahydro-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-, (8R,8aR,12aS)-(+)-
• CAS: 219649-95-3
• MF: C36H28O12
• MW: 652.61
• Mol File: 219649-95-3.mol

Griffipavixanthone Chemical Properties

• Boiling point: 862.8±65.0 °C(Predicted)
• density: 1.630±0.06 g/cm3(Predicted)
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: powder
• pka: 6?+-.0.70(Predicted)
• color: Yellow

Griffipavixanthone Usage And Synthesis

Uses

Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM)[1][2][3].

target

ROS | Caspase | RAF | MEK | ERK

References

[1] Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618. DOI:10.1080/14786419.2020.1716351
[2] Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31. DOI:10.3390/molecules19021422
[3] Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197. DOI:10.1007/s12282-018-0912-2