Introduction：Basic information about Heptaethylene Glycol Monomethyl Ether CAS 4437-01-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Heptaethylene Glycol Monomethyl Ether Basic information
| Product Name: | Heptaethylene Glycol Monomethyl Ether |
| Synonyms: | Heptaetheylene glycol methyl ether;mPEG7;HEPTAETHYLENE GLYCOL MONOMETHYL ETHER;Methoxyheptaethylene glycol, Monomethoxy-PEG (n=7);MPEG7-OH;Heptaetheylene glycol MonoMethyl ether;2,5,8,11,14,17,20-Heptaoxadocosan-22-ol;3,6,9,12,15,18,21-heptaoxadocosan-1-ol |
| CAS: | 4437-01-8 |
| MF: | C15H32O8 |
| MW: | 340.41 |
| EINECS: | |
| Product Categories: | Chemical Biology;Chemical Synthesis;Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols;High Oligomer Purity PEG;PEGylation;PEG-COOH;peg |
| Mol File: | 4437-01-8.mol |
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Heptaethylene Glycol Monomethyl Ether Chemical Properties
| Boiling point | 150 °C(Press: 0.005 Torr) |
| density | 1.09 |
| refractive index | 1.4540-1.4580 |
| storage temp. | -20°C |
| form | clear liquid |
| pka | 14.36±0.10(Predicted) |
| color | Colorless to Light yellow to Light orange |
| InChI | InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3 |
| InChIKey | AGWKUHGLWHMYTG-UHFFFAOYSA-N |
| SMILES | C(O)COCCOCCOCCOCCOCCOCCOC |
| CAS DataBase Reference | 4437-01-8(CAS DataBase Reference) |
Safety Information
| WGK Germany | 3 |
| HS Code | 29094990 |
| Storage Class | 10 - Combustible liquids |
Heptaethylene Glycol Monomethyl Ether Usage And Synthesis
| Description | m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. |
| Uses | Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization |
| Definition | The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1]. |
| reaction suitability | reagent type: cross-linking reagent |
| Synthesis | 112-60-7 74654-05-0 4437-01-8 A 60% NaH dispersion in mineral oil was added in batches to a stirred solution of triacetylene glycol (35.7 mmol) in anhydrous DMF (25.7 mL) under nitrogen protection, and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (23.36 mmol) in anhydrous DMF (4 mL) was added in a single addition to the resulting salt, and stirring was continued for 3.5 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC with 12% unfolding agent ratio). Upon completion of the reaction, the reaction mixture was diluted with an equal volume of 1N HCl, extracted with ethyl acetate (2 x 20 mL) and the organic phase discarded. The aqueous phase was extracted and post-treated to give heptaglycol monomethyl ether in 82-84% yield. |
| IC 50 | PEGs |
| References | [1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021). |
Heptaethylene Glycol Monomethyl Ether Preparation Products And Raw materials
| Raw materials | tetraethylene glycol-->Methyl-PEG3-MS-->Hexaethylene glycol-->1-Bromo-2-methoxyethane-->Ethanol, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, sodium salt (1:2)-->N,N-Dimethylformamide-->Sodium hydride |
| Preparation Products | mPEG6-CH2COOH-->m-PEG8-Tos-->m-PEG7-CH2COOH |
