Homosalate CAS 118-56-9
Introduction：Basic information about Homosalate CAS 118-56-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Homosalate Basic information
| Product Name: | Homosalate |
| Synonyms: | Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester;Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester;component of Coppertone;Coppertone;Filtersol ''A'';Filtrosol A;Heliopan;Homosalat |
| CAS: | 118-56-9 |
| MF: | C16H22O3 |
| MW: | 262.34 |
| EINECS: | 204-260-8 |
| Product Categories: | EUSOLEX |
| Mol File: | 118-56-9.mol |
Homosalate Chemical Properties
| Boiling point | 161-165°C (12 torr) |
| density | 1.05 |
| vapor pressure | 0.015Pa at 25℃ |
| refractive index | n20 1.516 to 1.518 |
| Fp | 169 - 173℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Liquid |
| pka | 8.10±0.30(Predicted) |
| color | Colourless |
| Odor | at 100.00?%. mild menthol |
| Water Solubility | <0.1 g/100 mL at 26 ºC |
| BRN | 2731604 |
| Cosmetics Ingredients Functions | FRAGRANCE UV ABSORBER UV FILTER |
| LogP | 6.27 at 25℃ |
| CAS DataBase Reference | 118-56-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Homosalate(118-56-9) |
| EPA Substance Registry System | 3,3,5-Trimethylcyclohexyl salicylate (118-56-9) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/39 |
| WGK Germany | 2 |
| TSCA | TSCA listed |
| HS Code | 29182300 |
| Description | Homosalate is an organic compound that belongs to a class of chemicals called salicylates. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, associated with DNA damage and an increased risk of skin cancer. It is a widely used chemical in sunscreens and skin care products with SPF. However, Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones. In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body. |
| Chemical Properties | Liquid. |
| Uses | Homosalate used as a UV filter in various personal skin care formulations and cosmetics. |
| Uses | UV screen, analgesic |
| Uses | homosalate is a chemical uVB absorber included in the FDA’s Category I Sunscreen Chemical list. Its approved usage level is 4 to 15 percent by the FDA and 10 percent by the european union’s Cosmetic Directive. |
| Definition | A homolog of menthyl salicylate. |
| Brand name | Eusolex (RonaLaboratories, Great Britain); Heliophan (Greeff). |
| General Description | Viscous or light yellow to slightly tan liquid or oil. |
| Air & Water Reactions | Homosalate will hydrolyze under basic conditions. . Insoluble in water. |
| Reactivity Profile | An ester and a phenol. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. |
| Fire Hazard | Homosalate is probably combustible. |
| Flammability and Explosibility | Non flammable |
| Side effects | Similar to oxybenzone, homosalate affects hormone activity once absorbed. Skin rashes, acne and skin irritation are rare side effects of the toxic chemical. Estrogen, androgen and progesterone have all been found to be disrupted when the body is exposed to homosalate. |
| Synthesis | 116-02-9 119-36-8 118-56-9 In a 250 mL three-necked flask, 10.0 g of methyl salicylate and 23.3 g of 3,3,5-trimethylcyclohexanol were added as reaction feedstock, followed by 0.50 g of potassium carbonate as a catalyst and 0.1 g of ammonium bromide as a co-catalyst. The reaction mixture was heated to 180 °C and the reaction was continued at this temperature for 13 hours. The conversion of methyl salicylate was monitored by gas chromatography during the reaction. Upon completion of the reaction, the products were separated using a vacuum distillation unit, and the fore grade fractions were recycled. Finally, 13.98 g of 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate was obtained as a colorless liquid with a yield of 81.1%, and the purity was analyzed by gas chromatography to be greater than 99%. |
| References | [1] Patent: CN105541634, 2016, A. Location in patent: Paragraph 0023; 0024 |
Homosalate Preparation Products And Raw materials
| Raw materials | Methyl salicylate-->3,3,5-Trimethylcyclohexanol |
