Introduction：Basic information about Hyaluronidase CAS 37326-33-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Hyaluronidase Basic informationDescription Source
| Product Name: | Hyaluronidase |
| Synonyms: | Hyaluronidase - CAS 37326-33-3 - Calbiochem;HYALURONATE GLYCANOHYDROLASE;HYALURONIDASE BOVINE TESTES;HYALURONIDASE OVINE TESTES;HYALURONIDASE, SALT-FREE, BOVINE;HYALURONIDASE, STREPTOMYCES HYALURONLYTICUS NOV SPECIES;HYALURONIDASE TYPE II;HYALURONIDASE TYPE III |
| CAS: | 37326-33-3 |
| MF: | NULL |
| MW: | 0 |
| EINECS: | 253-464-3 |
| Product Categories: | |
| Mol File: | Mol File |
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Hyaluronidase Chemical Properties
| storage temp. | -20°C |
| solubility | Soluble in water, practically insoluble in acetone and in anhydrous ethanol |
| form | powder |
| color | yellow-brown |
| biological source | sheep testis |
| Water Solubility | 0.5 M acetate, pH 6.0: 30U/mL
water: 30U/mL |
| Specific Activity | 750-3000units/mg solid |
| Major Application | diagnostic assay manufacturing |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
Safety Information
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 3-10 |
| HS Code | 35079090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Resp. Sens. 1 |
Hyaluronidase Usage And Synthesis
| Chemical Properties | White or yellowish-white, amorphous powder. |
| Uses | Used to promote absorption of fluid into tissues. |
| Uses | Hyaluronidase from sheep testes has been used:
- in flow cytometry
- in the isolation of putative spermatogonial stem cells (SSCs)
- to study the effects of magnetic stimulation in magnetic hydrogel properties
- in immunohistochemistry to visualize collagen type II distribution
- to expose group-III auditory neurons of Muller′s organ for patch-clamp recordings
- for the degeneration of hydrogels
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| Definition | Any of a class of soluble enzymes produced in mammalian testes that catalyze cleavage of glycosidicbonds of oartucular mucopolysaccharides. As acomponent of venoms, it reduces the viscosity ofconnective tissues and promotes tissue penetrationof the ve |
| General Description | Hyaluronidase is a hyaluronic acid-metabolizing enzyme. It is found in the venoms of snake, honeybee and hymenoptera. Hyaluronidase degrades hyaluronic acid (HA), which enhances membrane permeability, lowers viscosity and increases tissue permeability. It enhances the diffusion of local anesthetics, lowers the size of myocardial infarction, improves the effects of anticancer drugs and prevents perineal trauma during spontaneous delivery. |
| Biochem/physiol Actions | Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. |
| Purification Methods | Hyaluronidase is purified by chromatography on DEAE-cellulose prior to use. [Distler & Jourdain J Biol Chem 248 6772 1973.] |
| Description | Hyaluronidase is a glycoprotein isolated from bovine testes that degrades hyaluronan (HA) polymers. This enzyme hydrolyzes the endo-N-acetylhexosaminic bonds of hyaluronic acid, chondroitinsulfuric acid A, and chondroitinsulfuric acid C to tetrasaccharide rich oligosaccharides. Studies have shown that hyaluronidases have the potential for clinical utility as both biomarkers and therapeutic targets when looking at a variety of cancers. Hyaluronidase is an effective enzyme for tissue dissociation. |
| Source | Bovine |
Hyaluronidase Preparation Products And Raw materials
| Raw materials | Ammonium sulfate |
