Hydrangel 8-O-glucoside CAS 67600-94-6

Introduction：Basic information about Hydrangel 8-O-glucoside CAS 67600-94-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Hydrangel 8-O-glucoside Basic information

• Product Name: Hydrangel 8-O-glucoside
• Synonyms: Hydrangel 8-O-glucoside;Hydrangenol 8-O-glucoside;8-(beta-D-Glucopyranosyloxy)-3,4-dihydro-3-(4-hydroxyphenyl)-1H-2-benzopyran-1-one;hydrangenol 8-O-beta-D-glucopyranoside;1H-2-Benzopyran-1-one, 8-(β-D-glucopyranosyloxy)-3,4-dihydro-3-(4-hydroxyphenyl)-;3-(4-Hydroxyphenyl)-1-oxo-3,4-dihydro-1H-isochromen-8-ylβ-D-glucopyranoside
• CAS: 67600-94-6
• MF: C21H22O9
• MW: 418.39
• Mol File: 67600-94-6.mol

Hydrangel 8-O-glucoside Usage And Synthesis

Uses

Hydrangenol 8-O-glucoside (Hydrangenol 8-O-β-D-glucopyranoside) can be isolated from Hydrangea macrophyllu. Hydrangenol 8-O-glucoside is an AChE inhibitor (IC50: 22.66 μM). Hydrangenol 8-O-glucoside inhibits passive cutaneous anaphylaxis (PCA) reaction[1][2].

Definition

ChEBI: A member of the class of dihydroisocoumarins that is hydrangenol attached to a beta-D-glucopyranosyl residue at position 8 via a glycosidic linkage. It has been isolated from the roots of Scorzonera judaica.

References

[1] Matsuda H, et al. Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. Biol Pharm Bull. 1999 Aug;22(8):870-2. DOI:10.1248/bpb.22.870
[2] Hwang J, et al. Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches. Nutrients. 2021 Jan 17;13(1):254. DOI:10.3390/nu13010254