Hydroxyapatite CAS 1306-06-5
Introduction：Basic information about Hydroxyapatite CAS 1306-06-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Hydroxyapatite Basic information
| Product Name: | Hydroxyapatite |
| Synonyms: | CALCIUM PHOSPHATE, HYDROXIDE PURIFIED;Hydroxyapatite: (Calcium hydroxyapatite);Calcium phosphate hydroxide, Durapatite, Hydroxylapatite;CALCIUM PHOSPHATE, HYDROXIDE REAGENT;Apatite HAP;Hydroxyapatite,Calcium hydroxyphosphate, Calcium phosphate tribasic, HAp, Hydroxylapatite;Hydroxylapatite, for analysis 25GR;apatite,hydroxy |
| CAS: | 1306-06-5 |
| MF: | Ca5HO13P3 |
| MW: | 502.31 |
| EINECS: | 215-145-7 |
| Product Categories: | raw materials;Inorganics |
| Mol File: | 1306-06-5.mol |
Hydroxyapatite Chemical Properties
| Melting point | 1100 °C(lit.) |
| density | 3.076 g/cm3(Temp: 18 °C) |
| storage temp. | 2-8°C |
| solubility | H2O: 0.3 mg/mL, clear, colorless |
| form | solid |
| color | White |
| Water Solubility | insoluble H2O [MER06] |
| Merck | 13,3500 |
| Cosmetics Ingredients Functions | BULKING SKIN CONDITIONING ABRASIVE ORAL CARE |
| InChI | InChI=1S/2Ca.H3O4P.H2O/c;;1-5(2,3)4;/h;;(H3,1,2,3,4);1H2/q2*+2;;/p-4 |
| InChIKey | CGMRCMMOCQYHAD-UHFFFAOYSA-J |
| SMILES | [Ca+2].[Ca+2].P([O-])([O-])([O-])=O.[OH-] |
| CAS DataBase Reference | 1306-06-5(CAS DataBase Reference) |
| EPA Substance Registry System | Hydroxylapatite (Ca5(OH)(PO4)3) (1306-06-5) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | MY8434000 |
| F | 3-10 |
| TSCA | TSCA listed |
| HS Code | 28352600 |
| Storage Class | 13 - Non Combustible Solids |
| Hazardous Substances Data | 1306-06-5(Hazardous Substances Data) |
| Description | Calcium hydroxyapatite has a unique structure inthat it is conductive along the hydroxide channels.OH- ions lie at (1/4/,1/4,1/4) and (3/4/,3/4,3/4) onthe c-axis and charge-carrying protons are responsiblefor the observed conductivities in M10(PO4)6(OH)2. TheH+ migration between the electroattractive ion (O2)to give molecular H2O in matrix channels carries chargeand the resulting conductivity. The unit cell consists of two triangular prismatic subcellsforming a rhombic prism with vertical sides. Thereare two horizontal mirror planes at the OH levels of 1/4and 3/4 of the c-axis. In addition, there is a center ofinversion exactly in the center of each vertical face ofeach subcell. |
| Chemical Properties | Tricalcium phosphate is an odorless and tasteless powder that is stable in air. Tribasic calcium phosphate consists of avariable mixture of calcium phosphates having the approximate composition of 10CaO·3P2O5·H2O. |
| Chemical Properties | white powder |
| Occurrence | Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite. |
| Uses | Hydroxyapatite and tricalcium phosphate are bioactive ceramic materials and they find applications as bone grafts, fillers and coating material for metal implants. |
| Uses | Prosthetic aid (artificial bone and teeth). |
| Uses | In the 1970s, it was found that sintered calciumhydroxyapatite, (Ca10(PO4)6(OH)2 (abbreviated asCaHap), possessed excellent biocompatibility and nontoxicitywith femur and mandible bones. Since then,CaHap has been used as a biomaterial for artificial teethand bones and as a filler for cements and polymers.Today, bone fillers made of CaHap are widely used inthe medical and dental fields. In the 1980s, it was foundthat sintered CaHap has a good compatibility with skintissues. Hence, percutaneous devices based on CaHaphave been developed and applications have includedcontinuous ambulatory peritoneal dialysis and intravenoushyperalimentation systems, blood pressuremeasurement and blood access for nutrition. Recently,many researchers have studied the chemistry of apatites,particularly CaHap, and have found various applications,such as artificial teeth and bones, ion exchangers,adsorbents for chromatography to separate proteins andenzymes, catalysts, ionic conductors, temperature andgas sensors, etc. |
| Preparation | The technical product is also known as “bone ash.” Commercial preparation from phosphate rock. |
| Definition | The major constituent of bone and tooth mineral. It is finely divided, crystalline, nonstoichiometric material rich in surface ions (carbonate, magnesium, citrate), which are readily replaced by fluoride ion, thus affording protection to the teeth. |
| Brand name | Alveograf (Sterling Winthrop); Periograf (Sterling Winthrop). |
| General Description | Bone and tooth implant materials have been prepared from polycrystalline hydroxyapatite. The compressive, flexural, torsional and dynamic torsional strengths of polycrystalline hydroxyapatite were investigated. Electrophoretic deposition of hydroxyapatite on to flat titanium plate material has been studied. |
| Flammability and Explosibility | Not classified |
| Pharmaceutical Applications | Modified hydroxylapatite, also frequently called hydroxyapatite and better known as bone mineral, makesup ～50% of our bones. Hydroxylapatite is a natural form of the mineral calcium apatite, whose formula is usually denoted as Ca10(PO4)6(OH)2. Modifications of hydroxylapatite can also be found in the teeth, and achemically identical substance is often used as filler for replacement of bones, and so on. Nevertheless, despitesimilar or identical chemical compositions, the response of the body to these compounds can be quite different. |
Hydroxyapatite Preparation Products And Raw materials
| Preparation Products | Calcium phosphate monobasic-->Gelatin-->L-Tyrosine |
