Introduction：Basic information about IKF 309 CAS 688046-61-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
IKF 309 Basic information
| Product Name: | IKF 309 |
| Synonyms: | (5-Chloro-2-Methoxy-4-Methyl-3-pyridinyl)(2,3,4-triMethoxy-6-Methylphenyl)Methanone;3-(2,3,4-TriMethoxy-6-Methylbenzoyl)-5-chloro-2-Methoxy-4-Methylpyridine;IKF 309;Pyriofenone;Pyriofenone Solution;Methanone, (5-chloro-2-methoxy-4-methyl-3-pyridinyl)(2,3,4-trimethoxy-6-methylphenyl)-;IKF 309（Pyriofenone）;Pyriofenone 100 μg/mL in Acetonitrile |
| CAS: | 688046-61-9 |
| MF: | C18H20ClNO5 |
| MW: | 365.81 |
| EINECS: | |
| Product Categories: | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 688046-61-9.mol |
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IKF 309 Chemical Properties
| Melting point | 91-94°C |
| Boiling point | 519.8±50.0 °C(Predicted) |
| density | 1.214±0.06 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | -0.80±0.28(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability: | Light Sensitive |
| LogP | 4.469 (est) |
| EPA Substance Registry System | Methanone, (5-chloro-2-methoxy-4-methyl-3-pyridinyl)(2,3,4-trimethoxy-6-methylphenyl)- (688046-61-9) |
Safety Information
IKF 309 Usage And Synthesis
| Uses | Pyriofenone is a fungicide. |
| Uses | IKF 309 is a fungicidal imidazole derivative use for controlling plant diseases caused by fungal plant pathogens. |
| Definition | ChEBI: An aromatic ketone that is metrafenone in which the 3-bromo-6-methoxy-2-methylphenyl group is replaced by a 5-chloro-2-methoxy-4-methylpyridin-3-yl group. It is a fungicide developed for the control of powdery mildew in cereals and grape vines. |
| Synthesis | Production of IKF 309 (Pyriofenone) begins with methyl 2-chloro-4-methyl nicotinate. An SNAr (nucleophilic aromatic substitution) reaction introduces a methoxy group to the pyridine ring. The pyridine ring is selectively chlorinated to yield an intermediate compound which is subsequently hydrolysed to the corresponding acid, then converted to an acid chloride. The acid chloride reacts with 3,4,5-trimethoxy-toluene under Lewis acid catalysis to form the final ketone structure of pyriofenone. The final stage is purification and crystallisation. |
IKF 309 Preparation Products And Raw materials
