Indapamide CAS 26807-65-8

Introduction：Basic information about Indapamide CAS 26807-65-8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Indapamide Basic information

• Product Name: Indapamide
• Synonyms: N-(4-CHLORO-3-SULFAMOYLBENZAMIDO)-2-METHYLINDOLINE;N-[4-CHLORO-3-SULFAMOYL-BENZAMIDOL]-2-METHYLINDOLINE;INDAPAMIDE;3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid;3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide;4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-benzamid;natrilix;noranat
• CAS: 26807-65-8
• MF: C16H16ClN3O3S
• MW: 365.83
• EINECS: 248-012-7
• Product Categories: Cnbio;Intermediates & Fine Chemicals;Pharmaceuticals;Active Pharmaceutical Ingredients;Organics;API;Amines;Heterocycles;Indole Derivatives;Sulfur & Selenium Compounds;Drug bulk;Cardiovascular;Heterocycle-Indole series;LOZOL;Other APIs;26807-65-8
• Mol File: 26807-65-8.mol

Indapamide Chemical Properties

• Melting point: 160-162°C
• Boiling point: 110.4°C (rough estimate)
• alpha: -0.8～+0.8°(D/20℃) (c=5, C2H5OH)
• density: 1.2895 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: -20°C Freezer
• solubility: Practically insoluble in water, soluble in ethanol (96 per cent).
• pka: pKa (25°) 8.8 ± 0.2
• form: Solid
• color: White to Off-White
• Water Solubility: Soluble in ethanol. Insoluble in water
• Merck: 14,4935
• BCS Class: 1
• InChIKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N
• CAS DataBase Reference: 26807-65-8(CAS DataBase Reference)
• EPA Substance Registry System: Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)- (26807-65-8)

Safety Information

• WGK Germany: 2
• RTECS: CV2451200
• HS Code: 2935904000
• Toxicity: LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl)

Indapamide Usage And Synthesis

Diuretic antihypertensive drug

White needle crystal or crystalline powder, odorless, tasteless. It is almost insoluble in water or dilute hydrochloric acid, while it can be dissolved in ethanol or ethyl acetate, and it is soluble in acetone, acetic acid, slightly soluble in chloroform or ether.
Indapamide is currently the most popular non-prescription diuretic antihypertensive drug with good efficacy, stable blood pressure, fewer side effects, etc. It was originally developed for the first time by the French Servier (Servier) pharmaceutical company. Indapamide film-coated tablets were first successfully developed by Tianjin Lisheng pharmaceutical company in 1988 in China. The trade name is "life than the mountains." In the mid-1990s, Zhejiang Apeloa pharmaceutical, Yantai Xiyuan pharmaceutical factory, Zhejiang East medicine, Dongguan million into pharmaceuticals, Shanxi Asia-medicine, medicine Fuxin Shibata, Puyang the yuan Pharmaceutical, Chongqing Friends of pharmaceutical drugs, 8 pharmaceutical formulations were approved for production. In the late 1990s, the French pharmaceutical company Servier took indapamide sustained-release tablets into China. The trade name is "Na Ionizers." Subsequently, indapamide raw material drug localization has been progress. Currently, seven companies have been allowed to produce raw material drug types.
Indapamide have diuretic and calcium antagonist dual effect by inhibiting the proximal end of the distal convoluted tubule Na+ reabsorption, resulting in diuresis, while by blocking Ca2+ influx especially a higher selectivity for vascular smooth muscle to dilate the small blood vessels of the outer periphery, resulting in antihypertensive effect. But the effect to vascular smooth muscle is stronger than the diuretic effect. It can lower blood pressure with lower dose compared to diuretic effect. Higher dose will display diuretic effect. But there is no disadvantage compared to thiazide diuretics, that it does not cause orthostatic hypotension, flushing and reflex tachycardia, nor blood lipids, glucose metabolism and renal function. The therapeutic dosage for heart rate, cardiac output, electrocardiogram are no significant change, as well as for the central nervous system and autonomic. There is antihypertensive effect by oral for 2~3h, maintaining 24h. single medication has good effect. Diuretic effect appears at 3h, achieving maximum effect for 4~6h. It is different from other diuretics. This product is fat-soluble. After oral administration, there is highest concentration in the liver, renal plasma, and lower concentration in heart, lung, muscle, fat. This product excretes from the kidney mainly by metabolites and 5% of the prototype. Indapamide is for mild to moderate hypertension, and for sodium retention caused by congestive heart failure. It is also applied to hypertension with renal failure, diabetes mellitus, high blood lipids. Single medication has significant effect. It is combined with β-receptor blockers that has better effect. Because the drug has a diuretic effect, it can cause hypokalemia, which can add potassium.
The above information is edited by the chemicalbook of Kui Ming.

Uses

For the treatment of mild to moderate essential hypertension.

Category toxic

Substances

Toxicity grading

Medium toxicity

Acute toxicity

Oral-rat LD50:> 3000 mg/kg; Oral-mouse LD50:> 3000 mg/kg.

Flammability hazard characteristics

Combustible; combustion produces toxic nitrogen oxides, sulfur oxides and chlorides smoke.

Storage characteristics

Treasury ventilation low-temperature drying.

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, water mist.

Description

Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous tothat of thiazides. It is intended for lowering arterial blood pressure and as an adjuvant drug fortreating edema caused by cardiac insufficiency.  Indapamide can be detected in urine. This product is intended for research and forensic applications.

Chemical Properties

Crystalline Solid

Originator

Natrilix,Pharmacodex,W. Germany,1976

Uses

Used as an antihypertensive. Diuretic.

Definition

ChEBI: A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.

Manufacturing Process

A total of 8.9 parts of 3-sulfamyl-4-chloro-benzoylchloride in a solution of 50parts of anhydrous tetrahydrofuran are added portionwise in the course of 60minutes, while stirring, to a solution of 5.2 parts of N-amino-2-methyl indolineand 3.5 parts of triethylamine in 150 parts of anhydrous tetrahydrofuran. Thereaction mixture is left to stand 3 hours at room temperature, then theprecipitated chiorhydrate of triethylamine is filtered off. The filtrate isevaporated under vacuum and the residue is crystallized from a solution of 60parts of isopropanol in 75 parts of water. There are obtained 9 parts of N-(3-sulfamyl-4-chlorobenzamido)-2-methyl indoline, MP (K) 184° to 186°C, MP(MK) 160° to 162°C (isopropanol/water). [The melting points beingdetermined on a Kofler heater plate under the microscope (MK) or on a KoflerBank (K)].

Brand name

Lozol(Sanofi Aventis).

Therapeutic Function

Diuretic Indapamide

Clinical Use

Indapamide is an effectivediuretic drug when GFR falls below 40 mL/min. The duration of action is approximately 24 hours, with the normal oral adult dosage starting at 2.5 mg given each morning.The dose may be increased to 5.0 mg/day, but doses beyond this level do not appear to provide additional results.

Side effects

Effects on urine content and side effects are similar toeffects induced by thiazide diuretics.

Synthesis

Indapamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide(21.3.33), is synthesized from 2-methylendoline, the nitrosation of which gives 2-methyl-1-nitrosoindoline (21.3.31). Reducing this with lithium aluminum hydride leads to formationof 1-amino-2-methylendoline (21.3.32). Acylating this with 3-sulfonylamino-4-chlorbenzoicacid chloride leads to (21.3.33).

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity withNSAIDs; antagonism of diuretic effect.
Anti-arrhythmics: hypokalaemia leads to increasedcardiac toxicity; effects of lidocaine and mexiletineantagonised.
Antibacterials: avoid administration withlymecycline.
Antidepressants: increased risk of hypokalaemiawith reboxetine; enhanced hypotensive effect withMAOIs; increased risk of postural hypotension withtricyclics.
Antiepileptics: increased risk of hyponatraemia withcarbamazepine.
Antifungals: increased risk of hypokalaemia withamphotericin.
Antihypertensives: enhanced hypotensive effect;increased risk of first dose hypotension with postsynapticalpha-blockers like prazosin; hypokalaemiaincreases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases riskof ventricular arrhythmias with amisulpride;enhanced hypotensive effect with phenothiazines;hypokalaemia increases risk of ventriculararrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk ofventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemiaoccurs.
Ciclosporin: increased risk of nephrotoxicity andpossibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmiasdue to hypokalaemia with arsenic trioxide; increasedrisk of nephrotoxicity and ototoxicity with platinumcompounds.
Lithium excretion reduced (increased toxicity).

Metabolism

Indapamide is strongly bound to red blood cells, andis taken up by the vascular wall in smooth vascularmuscle according to its high lipid solubility. 60-70% ofa single oral dose is eliminated by the kidneys and 23%by the gastrointestinal tract. Indapamide is extensivelymetabolised with 5-7% of unchanged drug found inthe urine during the 48 hours following administration.About 16-23% of dose is excreted in the faeces

Indapamide Preparation Products And Raw materials

• Raw materials: 1-Amino-2-methylindoline hydrochloride-->4-Chloro-5-sulphamoylbenzoic acid-->INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS)-->2-Methylindolin-1-amine-->4-Chloro-3-sulfamoylbenzoyl chloride-->2-Methylindoline