Introduction：Basic information about INDOLE-3-GLYOXYLYL CHLORIDE CAS 22980-09-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
INDOLE-3-GLYOXYLYL CHLORIDE Basic information
| Product Name: | INDOLE-3-GLYOXYLYL CHLORIDE |
| Synonyms: | 3-INDOLYLGLYOXALYL CHLORIDE;3-INDOLYL-GLYOXYL CHLORIDE;3-INDOLEGLYOXYLYL CHLORIDE;ALPHA-OXO-INDOLE-3-ACETYL CHLORIDE;INDOLE-3-GLYOXYLOYL CHLORIDE;INDOLE-3-GLYOXYLYL CHLORIDE;(2-(3-INDOLYL)-2-OXOACETYL) CHLORIDE;alpha-Oxoindoleacetyl chloride |
| CAS: | 22980-09-2 |
| MF: | C10H6ClNO2 |
| MW: | 207.61 |
| EINECS: | 245-362-2 |
| Product Categories: | Aromtatics, Heterocycles, Indole Derivatives, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Building Blocks;Aromtatics;C10;Chemical Synthesis;Heterocyclic Building Blocks;Building Blocks;Heterocyclic Building Blocks;Indoles;Heterocycles;Impurities;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds |
| Mol File: | 22980-09-2.mol |
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INDOLE-3-GLYOXYLYL CHLORIDE Chemical Properties
| Melting point | 138 °C (dec.) (lit.) |
| Boiling point | 413.9±37.0 °C(Predicted) |
| density | 1.463±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.29±0.30(Predicted) |
| Sensitive | Moisture Sensitive |
| BRN | 147693 |
| InChI | 1S/C10H6ClNO2/c11-10(14)9(13)7-5-12-8-4-2-1-3-6(7)8/h1-5,12H |
| InChIKey | FPEGGKCNMYDNMW-UHFFFAOYSA-N |
| SMILES | ClC(=O)C(=O)c1c[nH]c2ccccc12 |
| CAS DataBase Reference | 22980-09-2(CAS DataBase Reference) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-27-36/37/39-45 |
| RIDADR | UN 1759 8/PG 2 |
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | II |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Skin Corr. 1B |
INDOLE-3-GLYOXYLYL CHLORIDE Usage And Synthesis
| Uses | INDOLE-3-GLYOXYLYL CHLORIDE is an indole derivative used in the preparation of reagents for chemiluminescent enzyme immunoassay. It is an impurity in the manufacture of tryptamines and related compounds. |
| Uses | • ;Reactant for preparation of dual IGF-1R/SRC inhibitors1• ;Reactant for preparation of indolylglyoxylamides as a new class of antileishmanial agents2• ;Reactant for preparation of glyoxyl analogs of indole phytoalexins as anticancer agents3• ;Reactant for diastereoselective synthesis of heptacyclic core of dragmacidin E4• ;Reactant for preparation of benzoylmethylpyrrolopyridinylethanedione as HIV-1 inhibitor5• ;Reactant for preparation of fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D16 |
| Uses | - Reactant for preparation of dual IGF-1R/SRC inhibitors
- Reactant for preparation of indolylglyoxylamides as a new class of antileishmanial agents
- Reactant for preparation of glyoxyl analogs of indole phytoalexins as anticancer agents
- Reactant for diastereoselective synthesis of heptacyclic core of dragmacidin E
- Reactant for preparation of benzoylmethylpyrrolopyridinylethanedione as HIV-1 inhibitor
- Reactant for preparation of fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1
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INDOLE-3-GLYOXYLYL CHLORIDE Preparation Products And Raw materials
| Preparation Products | Tryptophol-->Methyl indolyl-3-glyoxylate-->INDOLE-3-(N,N-DIMETHYL)GLYOXYLAMIDE-->1-(1H-Indol-3-yl)-2-morpholin-4-yl-2-oxoethanone |
