Introduction：Basic information about IODIPAMIDE CAS 606-17-7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
IODIPAMIDE Basic information
| Product Name: | IODIPAMIDE |
| Synonyms: | 3,3’-(adipoyldiimino)bis(2,4,6-triiodo-benzoicaci;adipiodon;3,3(ADIPOYLDIIMINO)BIS(2,4,6-TRIIODOBENZOIC ACID);3,3'-ADIPOYLDIIMINOBIS(2,4,6-TRIIODOBENZOIC ACID);2,2,4,4,6,6-hexaiodo-3,3-adipoyldiiminodi(benzoic acid);3,3'-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodobenzoic Acid;Adipic Acid Bis(3-carboxy-2,4,6-triiodoanilide);3-[[6-(3-carboxy-2,4,6-triiodo-anilino)-6-keto-hexanoyl]amino]-2,4,6-triiodo-benzoic acid |
| CAS: | 606-17-7 |
| MF: | C20H14I6N2O6 |
| MW: | 1139.76 |
| EINECS: | 210-105-5 |
| Product Categories: | Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 606-17-7.mol |
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IODIPAMIDE Chemical Properties
| Melting point | 306-308°C (dec.) |
| Boiling point | 908.6±65.0 °C(Predicted) |
| density | 2.5848 (estimate) |
| refractive index | nD21.5 1.3294 (c = 0.445 in methanol) |
| storage temp. | Room Temperature |
| solubility | DMSO (Slightly), Methanol (Very Slightly) |
| pka | pKa 3.5(H2O) (Uncertain) |
| form | Solid |
| color | White |
| Water Solubility | 0.46g/L(20 ºC) |
| Merck | 5022 |
| Major Application | pharmaceutical (small molecule) |
| InChIKey | FFINMCNLQNTKLU-UHFFFAOYSA-N |
| SMILES | OC(=O)c1c(I)cc(I)c(NC(=O)CCCCC(=O)Nc2c(I)cc(I)c(C(O)=O)c2I)c1I |
| EPA Substance Registry System | Benzoic acid, 3,3'-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo- (606-17-7) |
Safety Information
| WGK Germany | 3 |
| RTECS | DG0949500 |
| HS Code | 2924296000 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 606-17-7(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 2380 ±290, 4430 ±310 i.v. (Rosenberg) |
IODIPAMIDE Usage And Synthesis
| Chemical Properties | Crystalline Solid |
| Originator | Cholografin,Squibb,US,1954 |
| Uses | Diagnostic aid (radiopaque medium-cholecystographic). |
| Uses | antihypertensive, diuretic, activates K channels and AMPA receptors |
| Definition | ChEBI: Adipiodone is an organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. It has a role as a radioopaque medium. It is an organoiodine compound, a member of benzoic acids and a secondary carboxamide. It is a conjugate acid of an adipiodone(2-). |
| Manufacturing Process | 125 g of 2,4,6-triiodo-3-amino benzoic acid are dissolved in 250 cc ofchlorobenzene and 15 g of adipic acid dichloride are added at a temperaturebetween 110° and 130°C drop by drop to the solution. After evolution ofhydrochloric acid (about 2 to 3 hours) has ceased, the precipitated crudeadipic acid di-(3-carboxy-2,4,6-triiodo anilide) of the above formula is filteredhot with suction, washed with chlorobenzene, extracted by boiling withmethanol and, for purification, dissolved in an amount of methanolic causticsoda solution required for neutralization, filtered with charcoal, andprecipitated with dilute hydrochloric acid. Yield: 82.3 g, MP 306° to 308°C(with decomposition). |
| Brand name | Pharmaceutic necessity for IodipamideMeglumine [Injection]. Cholografin (Bristol-MyersSquibb). |
| Therapeutic Function | Diagnostic aid (radiopaque medium) |
| Hazard | Toxic by ingestion. |
IODIPAMIDE Preparation Products And Raw materials
| Raw materials | Adipoyl chloride-->3-Aminobenzoic acid |
