Introduction：Basic information about iodoxamic acid CAS 31127-82-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
iodoxamic acid Basic information
| Product Name: | iodoxamic acid |
| Synonyms: | 3-[3-[2-[2-[2-[3-(3-carboxy-2,4,6-triiodoanilino)-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2,4,6-triiodobenzoic acid;3,3'-[(1,16-Dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)diimino]bis(2,4,6-triiodobenzoic acid);3,3'-[Ethylenebis(oxyethyleneoxyethylenecarbonylimino)]bis(2,4,6-triiodobenzoic acid);B-10610;BC-17;SQ-21982;Iodoxamic;iodoxamic acid |
| CAS: | 31127-82-9 |
| MF: | C26H26I6N2O10 |
| MW: | 1287.92 |
| EINECS: | 250-478-1 |
| Product Categories: | |
| Mol File: | 31127-82-9.mol |
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iodoxamic acid Chemical Properties
| Boiling point | 977.7±65.0 °C(Predicted) |
| density | 2.423±0.06 g/cm3(Predicted) |
| pka | pKa 1.8/2.8(H2O,t = 25) (Uncertain) |
Safety Information
iodoxamic acid Usage And Synthesis
| Originator | Endobil,Bracco |
| Uses | Diagnostic aid (radiopaque medium). |
| Definition | ChEBI: Iodoxamic acid is an organic molecular entity. |
| Manufacturing Process | 148.5 g 4,7,10,13-tetraoxahexadecane-1,16-dinitrile (U.S. Patent No.2,401,607) was added to a solution of 232 g (2.45 mol) concentrate sulfuricacid in 290 ml absolute ethanol at 15°C. The mixture was heated at reflux for15 hours, cooled and poured into 1000 g ice and 250 g ammonium sulfate. Itwas extracted with methylene chloride, dried and a solvent was removed invacuum. The residue was distilled to give 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid dimethyl ester; BP: 190°-195°C/0.005 mm Hg.
1 mol above prepared diester was saponificated with equivalent of NaOH inwater. The reaction mixture was heated for 90 minutes. On cooling it wasextracted with ether and the water layer was evaporated to dryness. Theresidue was washed with acetone. The obtained disodium salt of 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid (yield 100%; MP: 102°-104°C) wasacidified with calculated quantity of HCl to give the dicarbonic acid. Thesolvent was evaporated to dryness. Acetone was added to the residue forremoving a by-product (sodium chloride) by filtration. Acetone was evaporatedand the residue was extracted with ether, dried and evaporated. The residualliquid was 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid.
100 ml thionyl chloride was cautious added to 56 g above prepared diacid andheated at 40°-50°C and excess thionyl chloride was distilled in vacuum. Theresidue was the 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic aciddichloride. The desired iodoxamic acid was prepared from above dichlorideand 3-amino-2,4,6-trijode benzoic acid, in dimethylacetamide |
| Brand name | Endobil (Bracco Industria Chimica S.p.A.,Italy); Endomirabil (Bracco Industria Chimica S.p.A.,Italy); Videocolangio (Bracco Industria Chimica S.p.A.,Italy). |
| Therapeutic Function | Diagnostic aid |
iodoxamic acid Preparation Products And Raw materials
| Raw materials | Thionyl chloride-->N,N-Dimethylacetamide-->2,6-Dibromopyridin-3-amine-->IOGLYCAMIC ACID |
