Iopromide CAS 73334-07-3
Introduction：Basic information about Iopromide CAS 73334-07-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Iopromide Basic information
| Product Name: | Iopromide |
| Synonyms: | 1,3-benzenedicarboxamide,n,n’-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino;6-triiodo-)-n-methyl-4;shl414c;IOPROMIDE;N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N'-methylbenzene-1,3-dicarboxamide;Iopromide（mixture of isomers）;Iopromid;oproMide |
| CAS: | 73334-07-3 |
| MF: | C18H24I3N3O8 |
| MW: | 791.11 |
| EINECS: | 277-385-9 |
| Product Categories: | Isotope Labelled Compounds;Amines;Aromatics;Diagnostic;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 73334-07-3.mol |
Iopromide Chemical Properties
| Melting point | broad (160?C transition) |
| Boiling point | 840.9±65.0 °C(Predicted) |
| density | 2.173±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Freely soluble in water and in dimethyl sulfoxide, practically insoluble in ethanol (96 per cent) and in acetone. |
| form | Solid |
| pka | 10.62±0.70(Predicted) |
| color | White to off-white |
| Stability: | Hygroscopic |
| Major Application | clinical |
| InChI | InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29) |
| InChIKey | DGAIEPBNLOQYER-UHFFFAOYSA-N |
| SMILES | C1(C(N(CC(O)CO)C)=O)=C(I)C(NC(COC)=O)=C(I)C(C(NCC(O)CO)=O)=C1I |
| CAS DataBase Reference | 73334-07-3(CAS DataBase Reference) |
| EPA Substance Registry System | 1,3-Benzenedicarboxamide, N1,N3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl- (73334-07-3) |
Safety Information
| Hazard Codes | N |
| Risk Statements | 50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | CZ2230000 |
| HazardClass | 9 |
| HS Code | 2924296000 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
| Toxicity | LD50 in mice, rats (g iodine/kg body weight): 16.5, 11.4 i.v. (Muetzel) |
| Description | Iopromide is a non-ionic, water-soluble X-ray contrast agent for intravascular administration. Iopromide can cause acute kidney injury and is used in animal models of contrast-induced nephropathy. |
| Chemical Properties | White Solid |
| Uses | Contrast molecule |
| Uses | Labelled Iopromide. Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium). |
| Definition | ChEBI: A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A ater soluble x-ray contrast agent for intravascular administration. |
| Brand name | Ultravist (Berlex). |
| General Description | Iopromide is a low-osmolar,nonionic monomer with 48% bound iodine content. It is indicatedfor use in angiography, excretory urography, andnumerous CT procedures. |
| References | [1] YOUNG-HWAN AHN. The potential utility of iodinated contrast media (ICM) skin testing in patients with ICM hypersensitivity.[J]. Journal of Korean Medical Science, 2015, 30 3: 245-251. DOI: 10.3346/jkms.2015.30.3.245 [2] JIN-YONG PARK. A new micro-computed tomography-based high-resolution blood-brain barrier imaging technique to study ischemic stroke.[J]. Stroke, 2014, 45 8: 2480-2484. DOI: 10.1161/strokeaha.114.006297 [3] KAMAL HASSAN Hassan F. Is hypoalbuminemia a prognostic risk factor for contrast-induced nephropathy in peritoneal dialysis patients?[J]. Therapeutics and Clinical Risk Management, 2014, 10: 787-795. DOI: 10.2147/tcrm.s70665 [4] NA WANG. Renal Protective Effect of Probucol in Rats with Contrast-Induced Nephropathy and its Underlying Mechanism.[J]. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 2015: 2886-2892. DOI: 10.12659/msm.895543 |
Iopromide Preparation Products And Raw materials
| Raw materials | 1,3-Benzenedicarboxamide, N3-[2,3-bis(acetyloxy)propyl]-N1-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-N1-methyl--->3-Methylamino-1,2-propanediol |
