Irbesartan CAS 138402-11-6

Introduction：Basic information about Irbesartan CAS 138402-11-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Irbesartan Basic information

• Product Name: Irbesartan
• Synonyms: 3-butyl-2-[[4-[2-(2h-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;2-BUTYL-3-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,3-DIAZASPIRO[4.4]NON-1-EN-4-ONE;IRBESARTAN;BMS-186295;AVAPRO;APROVEL;CS-1097;AVAPRO; SR-47436; BMS-186295
• CAS: 138402-11-6
• MF: C25H28N6O
• MW: 428.53
• EINECS: 604-078-2
• Product Categories: Aromatics;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;LITAREX;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Hypertension;Active Pharmaceutical Ingredients;Antihypertensive;API
• Mol File: 138402-11-6.mol

Irbesartan Chemical Properties

• Melting point: 180-181°C
• Boiling point: 648.6±65.0 °C(Predicted)
• density: 1.30±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: >25mg/mL
• pka: 4.16±0.10(Predicted)
• form: powder
• color: white to off-white
• Merck: 14,5083
• BCS Class: 2
• InChIKey: YOSHYTLCDANDAN-UHFFFAOYSA-N
• SMILES: N1C2(CCCC2)C(=O)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C=1CCCC
• CAS DataBase Reference: 138402-11-6(CAS DataBase Reference)
• EPA Substance Registry System: 1,3-Diazaspiro[4.4]non-1-en-4-one, 2-butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (138402-11-6)

Safety Information

• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 26-24/25
• WGK Germany: 3
• RTECS: HM2950270
• HS Code: 29332900
• Storage Class: 11 - Combustible Solids
• Hazardous Substances Data: 138402-11-6(Hazardous Substances Data)

Irbesartan Usage And Synthesis

Antihypertensives

Irbesartan is an angiotensin Ⅱreceptor inhibitor, angiotensin Ⅱ receptors are divided into AT1, AT2, irbesartan can inhibit AngⅠtransform into AngⅡby selectively blocking the AT1 receptor of AngⅡ, specifically antagonize angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is 8500 times than that of AT2, it can inhibit vasoconstriction and aldosterone release by selectively blocking the binding AngⅡ with AT1 receptor and result in the antihypertensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, and other hormone receptors, neither suppress the blood pressure regulation and the balance of sodium ion channels. Irbesartan can also reduce electrical remodeling of the myocardium, thereby reduce the mortality rate of patients with hypertension, it is the most effective drug for treatment of hypertension and cardiovascular disease.
Angiotensin antagonists (ARB) is applied to the clinical treatment of hypertension and diabetic nephropathy. At present, domestic drugs for treating high blood pressure are divided into angiotensin converting enzyme inhibitors (ACEI), calcium channel blockers, beta blockers and so on according to different working parts. By contrast, ARB has better antihypertensive effect, while Irbesartan is a new type of angiotensin antagonist which has clear antihypertensive effect, and has an important role in inhibiting left ventricular hypertrophy and protecting the kidneys.
According to foreign reports, it can quickly absorb by oral and the bioavailability is 60-80%, not affected by food. Plasma tmax is 1-1.5 hours, plasma protein combined rate is 90%, elimination half-life is 11-15 hours, reaching steady state in three days. By aldehyde oxidation acidification or glucose metabolism, vitro studies have shown that mainly oxidation by cytochrome enzymes of P450 and 2C9. This product and its metabolites excrete by biliary tract and kidney.
Irbesartan (Emberd) produced by Sanofi-aventis hangzhou minsheng pharmaceutical co., LTD won the approval of the SFDA used in the treatment of hypertension in type 2 diabetic nephropathy on March 8, 2007, and becomes China's first effective antihypertensive drug.

Telmisartan

Telmisartan is a new type of blood pressure drug, is a kind of specific angiotensin Ⅱ receptor (AT Ⅰ) antagonist, used in the treatment of essential hypertension. To instead of high affinity of angiotensin receptor Ⅱwith AT Ⅰ receptor subtypes (known angiotensin Ⅱ loci). Telmisartan has no effects in the AT Ⅰ receptor agonist sites, selectively combined with ATⅠ receptor and the combined effect is durable. Has no affinity with other receptor (including AT2 and other characteristics of less AT receptors). The other receptor function remains to be seen, excessive receptor stimulation effect due to telmisartan angiotensin Ⅱ level is also not known. Telmisartan is not inhibit human plasma renin, and also don't block the ion channel. Don't inhibit angiotensin converting enzymeⅡ, the enzyme can degrade and enhance adverse reactions caused by the excitation peptide inhibition. 80 mg of telmisartan in the human body is almost completely inhibit angiotensin Ⅱ causing increased blood pressure. Inhibition effect is last for a full of 24 hours and can still be detectable in 48 hours. Antihypertensive effect is obvious in 3 hours after the first dose. At 4 weeks after treatment began to gain maximum antihypertensive effect, and can be maintained in the long-term treatment. If the treatment was interrupted suddenly, the blood pressure returns to the treatment level in just a few days, rather than a resilient high blood pressure. In direct comparison of two kinds of high blood pressure drugs in clinical trials, treatment group was significantly lower than that of patients with dry cough angiotensin converting enzyme inhibitors in treatment group.
The above information is edited by the Chemicalbook of Duan Yalan.

Usage and Dosage

Oral: recommended starting dose of 0.15 g, 1 time a day. It can be increased to 0.3 g according to the condition, 1 time a day. Can be used alone, also can be shared with other anti-hypertensive drugs.
Severe hypertension and not satisfied with drop in blood pressure after the drug increment, can add with small dose of diuretic (such as thiazide) or other antihypertensive drugs.

Drug interaction

It has no obvious interactions with hydrochlorothiazide, digoxin, warfarin, nitrate benzene, pyridine.
It should be paid attention to when shared with diuretics due to insufficient blood volume and low sodium which can cause low blood pressure (hypotension). When shared with potassium diuretics (such as ammonia, benzene with organism), should avoid potassium increasing.
Do not affect each other pharmacokinetics when shared with digitalis drugs such as digoxin, beta blockers such as atenolol, calcium antagonists such as benzene, pyridine nitrate.

Overdose

After an overdose of this product can occur hypotension, tachycardia or bradycardia, vomiting, gastric lavage and support therapy should be adopted.

Side effects

Common adverse reactions: headache, dizziness, palpitation, etc., I have a cough, general degree is slight, the majority of patients continue to drugs are tolerated.
Rare urticaria and angioneurotic oedema.
Literature on this product is: the incidence of adverse reactions to more than 1% of indigestion, stomach burning, diarrhea, skeletal muscle pain, fatigue, and upper respiratory tract infection, but with the blank control group no significant difference.
Greater than 1% but less than control group in the incidence of abdominal pain, anxiety, nervousness, nausea, vomiting, chest pain, pharyngitis, skin rashes, tachycardia, etc. Low blood pressure and incidence of orthostatic hypotension is about 0.4%.

Chemical property

Crystallization from 96% ethanol, melting point is 180-181 ℃.

Uses

Antihypertensive drugs. Angiotensin Ⅱ-l (Ⅱ 1 A) receptor antagonist. Used to treat high blood pressure.

Production Method

Methods 1:
1-(fluorene methoxy carbonyl amino) ring e carboxylic acid (I) benzylamine reaction with 4-(2-phenyl cyano) amidation, product (Ⅲ) and water release N to produce compound (Ⅳ). (Ⅳ) and Triethyl orthobutyrate condensation, cyclization to compound (V), then azide to formation tetrazolium with sodium reaction to obtain Telmisartan.
Methods 2:
1-(fluorene methoxyl carbonyl amino) ring e carboxylic acid (I) condensation with compound(Ⅳ), the product remove N protection based to compound (Ⅷ), reacts with Triethyl orthobutyrate, obtain the product.

Description

Avapro was launched in Germany, the UK and the US for hypertension. Itcan be prepared in six steps starting with cyclopentanone or in three steps from 1-aminocyclopentanecarboxylic acid ethyl ester and pentanimidic ethyl ester. Avapro isan angiotensin Ⅱ receptor antagonist that is non-competitive and selective for AT,subtypes and has no AT₂ activity at postsynaptic receptors compared to presynatpic. Ithas no affinity for various non angiotensin Ⅱ receptor types in binding, no interactionwith calcium channels or antiports, and no affinity for α₁- and α₂--adrenoreceptors,serotonergic receptors, muscarinic m₁ and m₂ or other receptors. It is as potent assaralasin but with no agonist activity and is 10 times more potent than DuP753 in rats.It is similar in efficacy to enalapril (in those with severe hypertension) and atenolol,while more effective than losartan for mild to moderate hypertension.

Chemical Properties

Crystalline Solid

Originator

Sanofi (France)

Uses

An angiotensin II type 1 (AII1)-receptor antagonist

Uses

antidepressant

Uses

For the treatment of hypertension, as well as diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. Irbesartan is also used as a second line agent in the treatment of conges

Definition

ChEBI: A biphenylyltetrazole that is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.

Manufacturing Process

1. Synthesis of 2-n-Butyl-4-spirocyclopentane-2-imidazolin-5-one
Method 1:
The ethyl ester of 1-aminocyclopentanecarboxylic acid is prepared accordingto Adkins and Billica (J. Amer. Chem. Soc., 1948, 70, 3121).
Ethyl valerimidate hydrochloride is prepared according to Mac Elvain (J. Amer.Chem. Soc., 1942, 64, 1825-1827) and then freed from its hydrochloride byreaction with potassium carbonate and extraction with CH2Cl2.
The ethyl ester of 1-aminocyclopentanecarboxylic acid (1.57 g) and ethylvalerimidate (1.56 g) are dissolved in 12 ml of xylene containing 6 drops ofacetic acid. After refluxing for 6.5 h, the reaction medium is concentratedunder vacuum, the residue is chromatographed on silica gel using achloroform/methanol/acetic acid mixture (94/4/2; v/v/v) as the eluent. Thefraction containing the expected product is evaporated several times in thepresence of xylene and then benzene in order to remove the acetic acid. 1.91g of 2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one are obtained in theform of a thick oil.
Method 2:
1.97 g of sodium cyanide are dissolved in 3.9 ml of water in a roundbottomed flask and a solution containing 2.33 g of ammonium chloride in 5.9ml of water and 3.5 ml of 20% aqueous ammonia is added; finally, 3 g ofcyclopentanone in 3.8 ml of methanol are added to the flask. After stirring for1.5 h, the mixture is heated at 60°C for 45 min, heating is then stopped,stirring is continued for 45 min and the mixture is then cooled to 25°C. It isextracted several times with methylene chloride.
The 1-aminocyclopentanenitrile obtained is dissolved in 300 ml of acetone,and a solution of 2.25 g of oxalic acid dihydrate in 200 ml of acetone isadded, with stirring. The precipitate of 1-aminocyclopentanenitrile formed isfiltered off.
5.1 g of the oxalate obtained in the previous step are treated with 7.65 ml ofconcentrated sulfuric acid (d = 1.84) over 45 min, with stirring. The evolutionof a gas is observed and the temperature rises to 100°C. The mixture iscooled to about 35°C and poured into a mixture of ice and concentratedaqueous ammonia (10 g/2.8 ml). The suspension formed is extracted withchloroform containing 5% of methanol. The 1-aminocyclopentanecarboxamidewas obtained.
3 g of the compound prepared in the previous step are placed in 70 ml ofanhydrous THF and 3.3 ml of triethylamine, and 3 ml of valeryl chloride in 10ml of anhydrous THF are added, with stirring. A white suspension is formed.The intermediate which is formed, but not isolated, is 1-(Nvaleryl)aminocyclopentanecarboxamide. 6 g of potassium hydroxide pellets, 7ml of water and 16 ml of methanol are added. The mixture is refluxed for 2.5h and 9 g of ammonium chloride are then added. After stirring for 15 min, themixture is concentrated under vacuum. The residue of the 2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one obtained is taken up in water andextracted with ethyl acetate.
2. Synthesis of 2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)-methyl]-2-imidazolin-5-one
A mixture containing 250 mg of sodium hydride (as an 80% dispersion inmineral oil) and 5 ml of DMF is prepared under a nitrogen atmosphere and asolution containing 0.97 g of 2-n-butyl-4-spirocyclopentane-2-imidazolin-5-one in 10 ml of DMF is added dropwise. The mixture is stirred for 30 min at20°C and a solution of 1.5 g of 4-bromomethyl-2'-cyanobiphenyl in 10 ml ofDMF is then added. After stirring for 1 h at 20°C, the DMF is evaporated offunder reduced pressure, the residue is then taken up with ethyl acetate,filtered and evaporated. The residue of 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-nbutyl-4-spirocyclopentane-2-imidazolin-5-one is purefied by chromatography
1.56 g of the previous product, 2.6 g of tributyltin azide and 30 ml of xyleneare refluxed for 66 h. The xylene is then evaporated off and the residue isdissolved in 20 ml of CH2Cl2 and 5 ml of THF with the addition of 0.8 ml of 10N sodium hydroxide solution and, after stirring for 30 min, 2.5 g of tritylchloride, and the mixture is stirred for 26 h. After evaporation of the solvents,the residue is taken up in ethyl acetate in ethyl acetate, washed with waterand then with a 3% solution of potassium bisulfate and water. It is dried andevaporated. The residue is chromatographed on alumina using a hexane/ethylacetate mixture (9/1; v/v) as the eluent to give 1.97 g of the 2-n-butyl-4-spirocyclopentane-1-[(2'-(triphenylmethyltetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one. Melting point 150-152°C.
1.96 g of the product prepared in the previous step are dissolved in 10 ml ofmethanol and 10 ml of THF. After the reaction medium has been cooled to5°C, 1.5 ml of 4 N hydrochloric acid are added and the mixture is stirred for 3h at 20°C and 1 h at 30°C. After evaporation of the solvents, the residue istaken up in water and the pH is brought to 12 by the addition of 10 N sodiumhydroxide solution. The aqueous phase is extracted with ether, toluene andether again. The aqueous phase is acidified to pH 2 by the addition of 1 Nhydrochloric acid and then extracted with ethyl acetate and the extract isevaporated. The aqueous phase is acidified to pH 2 by the addition of 1 Nhydrochloric acid and then extracted with ethyl acetate and the extract isdried and evaporated. The white solid obtained is dried at 50°C under 0.05mm of mercury to give 840 mg of the 2-n-butyl-4-spirocyclopentane-1-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one. Melting point 180-181°C.

Brand name

Avapro(Sanofi Aventis);Aprovel/Avapro.

Therapeutic Function

Antihypertensive

General Description

Irbesartan, 2-butyl-3-[[29-(1H-tetrazol-5-yl)[1,19-biphenyl]-4-yl]methyl]1,3-diazaspiro[4,4]non-1en-4-one (Avapro), like losartan, possesses the acidic tetrazolesystem, which most likely plays a role, similar to the acidicgroups of angiotensin II, in binding to the angiotensin II receptor.In addition, the biphenyl system that serves to separatethe tetrazole from the aliphatic nitrogen is still present.A major difference in this agent is that it does not possessthe acidic side chain. Even so, irbesartan has good affinityfor the angiotensin II receptor because of hydrogen bondingwith the carbonyl moiety of the amide system. Also, thisparticular agent does not require metabolic activation ascandesartan does.

Biochem/physiol Actions

Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity. It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties. Irbesartan shows protective cardiovascular effects and provides protection against chronic glomerulonephritis.

Clinical Use

Angiotensin-II receptor antagonist:

Hypertension

Diabetic nephropathy

Veterinary Drugs and Treatments

Although experience in veterinary medicine is minimal irbesartanmay be useful in treating canine hypertension associated with renalinsufficiency. It may be effective in treating heart failure when dogsare unable to tolerate ACE inhibitors, but documentation for thisuse is lacking. One study, using very high irbesartan dosages (60mg/kg PO twice daily) in dogs with subacute mitral regurgitation,demonstrated no improvement in left ventricular function or preventionof left ventricular remodeling (Perry, Wei et al. 2002).

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect
. Analgesics: antagonism of hypotensive effect andincreased risk of renal impairment with NSAIDs;hyperkalaemia with ketorolac and other NSAIDs.
Antihypertensives: increased risk of hyperkalaemiahypotension and renal impairment with ACE-Is andaliskiren.
Ciclosporin: increased risk of hyperkalaemia andnephrotoxicity.
Diuretics: enhanced hypotensive effect;hyperkalaemia with potassium-sparing diuretics.
ESAs: increased risk of hyperkalaemia; antagonismof hypotensive effect.
Lithium: reduced excretion (possibility of enhancedlithium toxicity).
Potassium salts: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia andnephrotoxicity.

Metabolism

Following oral or intravenous administration of 14Cirbesartan, 80-85% of the circulating plasma radioactivityis attributable to unchanged irbesartan. Irbesartan ismetabolised by the liver via glucuronide conjugation andoxidation. The major circulating metabolite is irbesartanglucuronide (approximately 6%). In vitro studies indicatethat irbesartan is primarily oxidised by the cytochrome P450enzyme CYP2C9; isoenzyme CYP3A4 has negligible effect.Irbesartan and its metabolites are eliminated by bothbiliary and renal pathways. After either oral or IVadministration of [14C]-irbesartan, about 20% of theradioactivity is recovered in the urine, and the remainderin the faeces.

storage

Store at +4°C

Irbesartan Preparation Products And Raw materials

• Raw materials: Sodium azide-->Benzylamine-->Fluorene-->3-METHOXYPROPIONIC ACID-->Tetrazole-->ORTHO-N-VALERIC ACID TRIETHYL ESTER-->Triethyl orthobutyrate-->Valeryl chloride-->Cyclopentanone-->Triphenylmethyl Chloride-->Cycloleucine-->Sodium cyanide-->ETHYL PENTANIMIDATE-->Tributyltin azide-->Triethylamine-->4-Bromomethyl-2-cyanobiphenyl-->Oxalic acid dihydrate
• Preparation Products: METHYL TRIPHENYLMETHYL ETHER