Iron-dextran CAS 9004-66-4
Introduction：Basic information about Iron-dextran CAS 9004-66-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Iron-dextran Basic information
| Product Name: | Iron-dextran |
| Synonyms: | fe-dextran;fenate;ferdex100;ferricdextran;ferridextran;ferrodextran;ferroglucin;ferroglukin75 |
| CAS: | 9004-66-4 |
| MF: | FeH2O4S |
| MW: | 153.92348 |
| EINECS: | 202-785-7 |
| Product Categories: | API;API's;9004-66-4;john's |
| Mol File: | 9004-66-4.mol |
Iron-dextran Chemical Properties
| storage temp. | Room Temperature |
| solubility | Water (Slightly) |
| form | solution |
| color | Very Dark Red to Black |
| PH | 4 - 6.5 |
| biological source | synthetic |
| Water Solubility | Iron, ~100?mg/mL in water |
| InChI | InChI=1S/Fe.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4) |
| InChIKey | MVZXTUSAYBWAAM-UHFFFAOYSA-N |
| SMILES | [Fe].S(=O)(=O)(O[H])O[H] |
| IARC | 2B (Vol. 2, Sup 7) 1987 |
| EPA Substance Registry System | Iron dextran (9004-66-4) |
Safety Information
| Hazard Codes | Xn,T |
| Risk Statements | 40-42/43-43-45 |
| Safety Statements | 23-26-36/37/39-45-36-36/37-53 |
| WGK Germany | - |
| RTECS | NI2200000 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Carc. 1B Skin Sens. 1 |
| Hazardous Substances Data | 9004-66-4(Hazardous Substances Data) |
| Toxicity | LD50 i.v. in mice: 2240 mg Fe/kg (Beliles) |
| Description | Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible. It is supplied as a parenteral preparation and is used as a hematinic. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1292) Iron-Dextran is for the parenteral treatment of iron-deficiency anemia in humans and baby pigs. Can be used as a reagent. |
| Chemical Properties | Light to dark brown powder. Colloidal suspension of an iron-dextran complex in water. pH 5.2-6.5. |
| History | The therapeutic value of colloidal iron preparations was first reported in the 1950's by London and Twigg. Numerous attempts have been made to improve these iron preparations Thus dextran ([h] 0.05) is first heated with alkali, and is then neutralized in the presence of ferric chloride solution. Studies on this product have revealed that each particle consists of a central iron core, approximately 3nm diameter, surrounded by a dextran sheath of approximately 13nm diameter. The complex is visualized as a particle formed by a protective sheath of dextran attached by terminal metasaccharinic acid units to a b-FeOOH core. A solution of this complex containing 5% iron and 20% dextran (Imferon ™ ) is suitable for intramuscular and intravenous injection for treating iron deficiency anemia. The product is currently used widely for treating anemia in new-born piglets. The use of these preparations has been re-examined in humans and a dramatic rise in hemoglobin was reported following intravenous infusion. The solution is best administered together with glucose solutions. |
| Uses | Hematinic. |
| Uses | Iron-Dextran (ferric hydroxide dextran complex) may be used as an intravenous iron delivery preparation. Iron-Dextran may be used to induce iron-overload to study its effects and preventative measures. |
| Brand name | Dexferrum (Luitpold); Infed (Wat son); Proferdex (New River). |
| Reactivity Profile | Iron-dextran is unstable at a pH of 5 and decomposes at 149-158° F. Iron-dextran may be sensitive to prolonged exposure to air. |
| Health Hazard | SYMPTOMS: The symptoms associated with exposure to Iron-dextran are headaches, vomiting, and dizziness. |
| Fire Hazard | Iron-dextran is combustible. |
| Clinical Use | Prophylaxis of iron deficiency anaemia (when oraltreatment is ineffective or contraindicated) Treatment of iron deficiency during ESA therapyespecially if serum ferritin is very low (<50nanograms/mL) |
| Drug interactions | Potentially hazardous interactions with other drugs Dimercaprol: avoid concomitant use. Oral iron: reduced absorption of oral iron |
| Carcinogenicity | Iron dextran complex is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. |
| Metabolism | After intravenous infusion, iron dextran is taken up bythe cells of the reticuloendothelial cells, particularly in theliver and spleen. The reticuloendothelial cells graduallyseparate iron from the iron-dextran complex. Mostabsorbed iron is bound to transferrin and transportedto the bone marrow where it is incorporated intohaemoglobin; the remainder is contained within thestorage forms, ferritin or haemosiderin, or as myoglobin,with smaller amounts occurring in haem-containingenzymes or in plasma bound to transferrin. Only very small amounts of iron are excreted as themajority released after the destruction of the haemoglobinmolecule is re-used. |
Iron-dextran Preparation Products And Raw materials
| Preparation Products | Dextran |
