ISOTETRANDRINE CAS 477-57-6

Introduction：Basic information about ISOTETRANDRINE CAS 477-57-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

ISOTETRANDRINE Basic information

• Product Name: ISOTETRANDRINE
• Synonyms: 1-isotetrandrine;6,6’,7,12-tetramethoxy-2,2’-dimethyl-berbama;isosinomenina;isosinomeninea;o,o’-dimethylobamegine;o,o’-dimethylstepholine;O-METHYLBERBAMINE;BERBAMINE METHYL ETHER
• CAS: 477-57-6
• MF: C38H42N2O6
• MW: 622.76
• Product Categories: Alkaloids
• Mol File: 477-57-6.mol

ISOTETRANDRINE Chemical Properties

• Melting point: 180-182℃
• Boiling point: 710.5±60.0 °C(Predicted)
• density: 1.172
• RTECS: NX7285000
• solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
• form: Off-white solid.
• pka: 7.70±0.20(Predicted)
• color: White to light yellow
• InChIKey: WVTKBKWTSCPRNU-PKGWHCLJNA-N
• SMILES: O(C1C(=CC2CCN(C)[C@]3([H])CC4=CC=C(OC)C(OC5C=CC(=CC=5)C[C@]5([H])N(C)CCC6C=C(OC)C(=CC=65)OC=1C3=2)=C4)OC)C |&1:9,27,r|

ISOTETRANDRINE Usage And Synthesis

Description

A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]¹⁷_D + 146° or[α]²⁰_D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

Uses

Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

target

IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK

References

Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
Synthesis:
Inubushi et ai., Tetrahedron Lett., 3399 (1968)