Introduction：Basic information about LEVOCABASTINE CAS 79516-68-0, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
LEVOCABASTINE Basic information
| Product Name: | LEVOCABASTINE |
| Synonyms: | Levocabastine & Levocabastine Hydrochloride;(3S,4R)-1-[cis-4-Cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;(3S,4R)-1-(4-Cyano-4-(4-fluorophenyl)cyclohexyl)-3-Methyl-4-phenylpiperidine-4-carboxylic acid;LEVOCABASTINE;(3S,4R)-3-methyl-4-phenyl-1-[(1s,4s)-4-cyano-4-(4-fluorophenyl)cyclohexyl]piperidine-4-carboxylic acid;4-Piperidinecarboxylic acid, 1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, [3S-[1(cis),3a,4b]]-;4-Piperidinecarboxylic acid, 1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-, (3S,4R)- (9CI);(3S)-1-[4α-Cyano-4-(4-fluorophenyl)cyclohexan-1α-yl]-3β-methyl-4-phenylpiperidine-4α-carboxylic acid |
| CAS: | 79516-68-0 |
| MF: | C26H29FN2O2 |
| MW: | 420.52 |
| EINECS: | |
| Product Categories: | |
| Mol File: | 79516-68-0.mol |
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LEVOCABASTINE Chemical Properties
| Boiling point | 589.9±50.0 °C(Predicted) |
| density | 1.23 |
| pka | 3.57±0.40(Predicted) |
Safety Information
LEVOCABASTINE Usage And Synthesis
| Chemical Properties | Levocabastine Hydrochloride: C26H29FN2O2?HCl. [79547-78-7]. Crystalline, melting point 298-299°C. |
| Originator | Livostin,Janssen-Cilag,Belgium |
| Uses | Anti histaminic. |
| Definition | ChEBI: Levocabastine is a member of piperidines. |
| Manufacturing Process | 4-Cyano-4-(4-fluorophenyl)-heptanedioic acid diethyl ester is obtained byaddition of ethyl acrylate to the anion from p-fluorophenylacetonitrile. By basecatalyzed cyclization of these diester (sodium methoxide, 60°C, xylene) issynthesized an intermediate that after decarboethoxylation gives 1-(4-fluorophenyl)-4-oxycyclohexanecarbonitrile. By condensation of 3-methyl-5-phenylpiperidine-4-carboxylic acid benzyl ester and 1-(4-fluorophenyl)-4-oxycyclohexanecarbonitrile under reductive hydrogenation conditions(palladium-on-charcoal catalyst, 50°C, in ethanol) is prepared benzyl ester 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))-. The benzyl protecting group is then removedby hydrogenation method and 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, (3S-(1(cis),3α,4β))- obtained istransformed into 4-piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, hydrochloride, (3S-(1(cis), 3α,4β))-(Levocabastine hydrochloride) |
| Brand name | Livostin (Novartis). |
| Therapeutic Function | Antihistaminic |
LEVOCABASTINE Preparation Products And Raw materials
| Raw materials | Ethyl acrylate-->4-Fluorophenylacetonitrile-->Sodium Methoxide |
