Linarin CAS 480-36-4

Introduction：Basic information about Linarin CAS 480-36-4, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Linarin Basic information

• Product Name: Linarin
• Synonyms: LINARIN;BUDDLEOSIDE;BUDDLOSIDE;ACACETIN-7-O-RUTINOSIDE;ACACETIN-7-RUTINOSIDE;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-4'-methoxyflavone;7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one;7-((6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(4-methoxyphenyl)-4H-benzopyran-4-one
• CAS: 480-36-4
• MF: C28H32O14
• MW: 592.55
• EINECS: 207-547-6
• Product Categories: Tri-substituted Flavones;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 480-36-4.mol

Linarin Chemical Properties

• Melting point: 258-260°C
• Boiling point: 885.2±65.0 °C(Predicted)
• density: 1.62±0.1 g/cm3(Predicted)
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: Acetic Acid (Very Slightly, Heated), Acetonitrile (Slightly), DMSO (Slightly)
• form: Solid
• pka: 6.11±0.40(Predicted)
• color: White to Pale Beige
• Stability: Hygroscopic
• Major Application: food and beverages
• InChIKey: YFVGIJBUXMQFOF-BWLJPJRBNA-N
• SMILES: C12C(O)=CC(O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@@H]4O[C@H]([C@H](O)[C@@H](O)[C@H]4O)C)O3)O)=CC=1OC(C1C=CC(OC)=CC=1)=CC2=O |&1:6,7,9,10,12,15,17,18,20,22,r|
• CAS DataBase Reference: 480-36-4(CAS DataBase Reference)

Safety Information

• Safety Statements: 22-24/25
• WGK Germany: WGK 3
• HS Code: 29389090
• Storage Class: 11 - Combustible Solids

Linarin Usage And Synthesis

Chemical Properties

White crystalline powder, easily soluble in methanol, almost insoluble in ether, derived from wild chrysanthemum, great thistle, and small thistle.

Uses

Linarine (Diosmin EP Impurity E) is a naturally occurring flavone glycoside that was identified to possess potential sedative and anticonvulsant properties.

in vivo

Linarin (oral administration; 50-150 mg/kg; 8 weeks) can improve bone loss in ovariectomized mice^[2].

• Animal Model: Ovariectomy treated female C57/BL6 mice^[2]
• Dosage: 50 and 150 mg/kg
• Administration: Oral administration (p.o.); 8 weeks
• Result: Dose?dependently preserved the trabecular bone microarchitecture of ovariectomized mice. Slightly increased BMD compared to the control OVX group. Significantly decreased OVX-induced serum ALP and OCN levels.

IC 50

AChE