Introduction：Basic information about Lincomycin hydrochloride monohydrate CAS 7179-49-9, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Lincomycin hydrochloride monohydrate Basic information
| Product Name: | Lincomycin hydrochloride monohydrate |
| Synonyms: | d-erythro-d-galacto-octopyranoside,methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-,monohydrochloride,hemihydrate;frademicina;lincocinhydrochloridehydrate;lincomycin,hydrochloride,hemihydrate;lincomycin,hydrochloridehydrate;methyl6,8-dideoxy-6-(1-methyl-4-propyl-2-d-erythro-d-galacto-octopyranosid;mycivin;lincocin hydrochlohydrate |
| CAS: | 7179-49-9 |
| MF: | C18H37ClN2O7S |
| MW: | 461.01 |
| EINECS: | 615-424-7 |
| Product Categories: | Antibiotics;Interferes with Protein SynthesisAnalytical Standards;LSpectrum of Activity;MLSMore...Close...;Alphabetic;Antibacterial;Antibiotics A to;Antibiotics G-MAntibiotics;Chemical Structure;Chemical Structure Class;L - ZAntibiotics;MacrolidesAntibiotics;Mechanism of Action;LINCOCIN |
| Mol File: | 7179-49-9.mol |
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Lincomycin hydrochloride monohydrate Chemical Properties
| Melting point | 156-158° |
| alpha | D25 +143° (water) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Very soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in acetone. |
| form | Solid |
| color | White to Almost white |
| Merck | 14,5500 |
| Major Application | clinical testing |
| InChIKey | LFZGYTBWUHCAKF-DCNJEFSFSA-N |
| SMILES | Cl[H].[H]O[H].CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O |
| CAS DataBase Reference | 7179-49-9(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-24/25 |
| WGK Germany | 2 |
| RTECS | RH6315500 |
| HS Code | 29419090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
Lincomycin hydrochloride monohydrate Usage And Synthesis
| Chemical Properties | White or almost white, crystalline powder. |
| Uses | antibacterial |
| Brand name | Lincocin (Pharmacia & Upjohn). |
| Contact allergens | Lincomycin is an antibiotic of the lincosanide group，active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders |
| in vivo | Lincomycin (25 and 50 mg/kg, intravenously) depresses neuromuscular transmission to a degree which depended on stimulation frequencies in the rabbit sciatic nerve-gastrocnemius muscle preparation[3].
| Animal Model: | Adult albino New Zealand rabbits weighing 2.5-3.5 kg[3]. | | Dosage: | 25 and 50 mg/kg. | | Administration: | Intravenously. | | Result: | Depressed neuromuscular transmission. |
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Lincomycin hydrochloride monohydrate Preparation Products And Raw materials
| Raw materials | Sodium hydroxide-->Hydrochloric acid-->Ammonium hydroxide-->Acetone-->1-Butanol-->Ammonium sulfate-->Oxalic acid-->Ammonium nitrate |
| Preparation Products | Clindamycin hydrochloride |
